Nanotechnology:

Shiv Majumdar's picture
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Nanotechnology:
The aim of nanoparticles in drug delivery is to improve drug uptake and specificity while also reducing side-effects. These aims can be achieved through drug encapsulation, reduced immune response and improved drug targeting and delivery.
Nanoparticles provide massive advantages regarding drug targeting, delivery and release and, with their additional potential to combine diagnosis and therapy, nanoparticles will emerge as one of the major tools in nanomedicine as anti-tumor therapy, gene therapy, AIDS therapy and radiotherapy
There has been a substantial increase in the patent activity in the area of nanoparticles and encapsulation since 2001. Over 90 patent filings a year have been made since 2004
With over 50 patent filings since 1997, Elan easily dominates this field of research and patent filing.
Central to Elan’s success has been their NanoCrystal technology which it has licensed to a number of big pharma companies
The majority of the other leading entities are research institutes although 3M Innovations also appears in the top 10, as well as being seventh in the transdermal drug delivery area

Major Companies:
Acusphere, Camurus, CytImmune Sciences, Do Coop Technologies, Elan, Shimoda Biotech etc

SUPRIYA VAVILAPALLI's picture

nano technology is blooming

4

nano technology is blooming up at faster rates now a days due to patent acceptance and comfort.......

SUPRIYA VAVILAPALLI

THE COGNITIVE MOLECULES

Shiv Majumdar's picture

User friendly dosage form

Dear Supriya,

The nanotechnology increases patient acceptance & comfort as you mention, moreover it increases bioavailability also so they are preferred more.

Regards
Shiv
Team 'INFINITY'

Santosh Kumar. JH's picture

Anti- tumour therapy.....

4

Dear Sir,

I would like to know how far this nanoparticle encapsulted drug moiety can overcome the drug resistance offered by drug efflux transporters like P-gp,MRP1 in cancer therapy ?

Regards,
Santosh Kumar
http://www.pharmainfo.net/santosh-kumar-jh
"PHARMERS"

"PHARMERS"

Shiv Majumdar's picture

Your query

Dear Santosh,

About overcoming the drug resistance offered by drug efflux transporters like P-gp,MRP1 in cancer therapy by nanotechnology, yes it has promising effect.
Resistance to cancer chemotherapy is due to altered drug activity at designed target and modified intra-tumour pharmacokinetic (Uptake & metabolism).
Medical applications of nanoparticular systems have attracted considerable attention because of their potential use in therapeutic targeting of disease tissues and their lower level of toxicity against healthy tissue, relative to traditional pharmaceutical drugs. The use of nanoparticular systems has been shown to overcome the limitations of most anticancer drugs in clinical applications. In particular, the improved performance of smarted nanoparticular system for solving the drug resistance problems that typically interrupt tumor treatment has provided a promising strategy for successful tumor chemotherapy.
eg. Poly(alkylcyanoacrylate) [PACA] nanoparticles were found to overcome Multi-drug resistance phenomena at both cellular & non-cellular level.

Reference: 1) Mansoor M. Amiji, "Nanotechnology for cancer therapy" CRC Press, Taylor & Francis Group, Page No. 268-70
2) Kyung Taek Oh et.al., "The Reversal of Drug-Resistance in Tumors Using a Drug-Carrying Nanoparticular System", Int. J. Mol. Sci. 2009, 10, 3776-3792; doi:10.3390/ijms10093776

Zarrin Faria's picture

Dear sir, Please elaborate on

4

Dear sir,
Please elaborate on the types of nanoparticles..
Regards,
Faria Zarrin
Team: BLOGBUSTERS

Shiv Majumdar's picture

Types

Fullerenes: Buckyballs and Carbon tubes
Liposomes
Nanoshells
Dendrimers
Quantum dots
Superparamagnetic nanoparticles
Nanorods

Regards
Shiv
Team 'INFINITY'

Sirisha Pingali's picture

sir.. These types you

sir..
These types you mentioned are very interesting..I think compared to others, liposomes are a point of study..can you tell me briefly about buckyballs?

Sirisha Pingali
www.pharmainfo.net/sirisha

Shiv Majumdar's picture

Bulkyballs

Dear Sirisha,

About Bulkyballs,

Buckminsterfullerenes, or buckyballs as they are more commonly known, are the spherical equivalent to carbon nanotubes. The carbon lattice in buckyballs consists of pentagonal carbon chain surrounded by hexagonal chains in a pattern much like that of a soccer ball. This pattern allows the carbon lattice to bend in a way that is most stable in a hollow spherical form.
The most immediately apparent contributions that these buckyballs may make lie in the field of drug delivery and transport within the body. Currently, liposomes are used to transport drugs through the body for a slower acting and longer lasting effect with better localization to target areas. These liposomes can be introduced through many different methods, including inhalation. However, these liposomes are often targeted by killer cells in our immune system and tend to be cleared from lung tissue very quickly, decreasing the effectiveness of the drug.
Buckyballs have recently been proposed as a potential replacement for liposomes in this type of drug delivery. The superior biological stability of buckyballs allows them to be retained in the lung much longer than liposomes for better drug delivery. Moreover, the simple lattice structure of these buckyballs make it easy to attach multiple drugs to the system, allowing for drug cocktails designed for more complicated action on target sites. A recent article published in the JACS demonstrated that when coupled with cancer drug, Paclitaxel, these buckyballs show an ability to remain in the lung longer than traditional liposomes.
A lab in Cornell is currently researching a method of creating buckyballs out of DNA molecules, and several other labs are working on further potential uses for these balls. Further applications include uses as molecular ball bearings, optical devices, and semiconductors.

Regards
Shiv
Team 'INFINITY'

Sirisha Pingali's picture

sir.. Thats very interesting

sir..
Thats very interesting to know about this..Thank you for your quick reply..

Sirisha Pingali
www.pharmainfo.net/sirisha