Old Drug but New Use

majumdarshiv's picture
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majumdarshiv
Wednesday, December 23, 2009 - 10:14

The most rational basis for the discovery of a new drug is to start with an old drug. If we consider compounds that have been discontinued in the market for reasons other than safety, it reasonably makes sense to look at failed compounds first when identifying new chemical entities to satisfy unmet medical need. After all, these have already been proven to be safe, just not effective in the original indication

ASPIRIN-Over 100 years ago, aspirin became the first drug to be made synthetically, and its marketing laid the foundation of the modern pharmaceutical industry. It is still the benchmark against which other analgesics are measured. The new uses of aspirin are
Dementia A reduction in cognitive decline and dementia in patients who take aspirin has been suggested. If confirmed, this will be of enormous importance to public health. Lesser degrees of damage from vascular lesions may also be prevented by low-dose aspirin. Evidences from a number of trials are urgently needed but results from one trial have already suggested benefit.
Another form of dementia is Alzheimer's disease. A large number of studies have shown a reduced incidence of Alzheimer's disease in patients taking aspirin or other anti-inflammatory drugs
Cataracts An association between regular aspirin use and reduced development of cataract has been reported.

In coming blogs, I'll discuss few such examples

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Comments

drgunasakaran1's picture

drgunasakaran1

Wed, 12/23/2009 - 10:31

Dear Sir,

Awesome blog.

Dr.S.Gunasakaran,MBBS,MD. Head - Clinical Research & Medical Affairs www.clinicalresearchsociety.org/forum
majumdarshiv's picture

majumdarshiv

Thu, 12/24/2009 - 06:59

Dear Sir,

Thanks for the compliment.

Keep suggesting & send your valuable comments.

Regards
Shiv

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manthan.janodia

Wed, 12/23/2009 - 10:31

Dear Shiv,
Good Blog. One such drug is Minoxidil. Used as an antihypertensive. Now used in treatment of alopecia.

Blogbusters Manthan D.Janodia
sirisha's picture

sirisha

Thu, 12/24/2009 - 04:43

yes sir..
Heard of this news recently..i think its applied as a lotion.,..

Sirisha Pingali

http://www.pharmainfo.net/sirisha

majumdarshiv's picture

majumdarshiv

Thu, 12/24/2009 - 07:47

Dear Manthan.

Thanks for the comment. as I wrote in earlier blog about side effect used as therapeutic effect (Viagra) same thing happen in case of minoxidil, its side effect is hypertrichosis (hairr growth) so that is used as therapeutic effect.

Thanks for the addition.

Reagrds
Shiv

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majumdarshiv's picture

majumdarshiv

Thu, 12/24/2009 - 07:47

Dear Manthan.

Thanks for the comment. as I wrote in earlier blog about side effect used as therapeutic effect (Viagra) same thing happen in case of minoxidil, its side effect is hypertrichosis (hairr growth) so that is used as therapeutic effect.

Thanks for the addition.

Regards
Shiv

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vbsishwarya's picture

vbsishwarya

Wed, 12/23/2009 - 13:08

Dear sir,
Its nice to hear such interesting concept..........
Waiting for your further blogs.
Regards,

Regards V.B.S.Aishwarya CREATIVE DIVISION RCP http://www.pharmainfo.net/og/rcp/soldiers-rcp
majumdarshiv's picture

majumdarshiv

Thu, 12/24/2009 - 07:48

Dear Aishwarya,

Thanks for the compliment, keep reading definitely we'll try to put some more interesting blogs.

Regards
Shiv

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sudha's picture

sudha

Wed, 12/23/2009 - 15:42

Old Drug, New Use: New Research Shows Common Cholesterol-Lowering Drug Reduces Multiple Sclerosis Symptoms in Mice.
http://www.ninds.nih.gov/news_and_events/news_articles/news_article_old_...

REGARDS,

Regards,

Sudha.T

majumdarshiv's picture

majumdarshiv

Thu, 12/24/2009 - 07:49

Dear Sudha,

Thanks for the addition in the blog.

keep suggesting.

Regards
Shiv

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santosh kumar. JH's picture

santosh kumar. JH

Wed, 12/23/2009 - 16:11

Dear Sir...,

In one of the study it was revealed that taking aspirin every alternate day will significantly reduce the risk of blindness.

Ref: www.indianexpress.com/news/Aspirin---cuts-blindness-risk--/549022

Regards, Santosh Kumar http://www.pharmainfo.net/santosh-kumar-jh
majumdarshiv's picture

majumdarshiv

Thu, 12/24/2009 - 07:50

Dear Santosh,

Thanks for the additional knowledge, keep suggesting.

Regards
Shiv

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sirisha's picture

sirisha

Thu, 12/24/2009 - 04:44

sir..
really informative..Althogh aspirin carries some side effects but its the most often prescribed analgesic and antiplatelet too. keep blogging sir..

Sirisha Pingali

http://www.pharmainfo.net/sirisha

majumdarshiv's picture

majumdarshiv

Thu, 12/24/2009 - 07:52

Dear Sirisha,

Yeah although aspirin has many lacunae but its potency gave it preference over others.

Regards
Shiv

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kranthikumar's picture

kranthikumar

Thu, 12/24/2009 - 07:49

GOod information sir.

Regards Kranthi http://www.pharmainfo.net/kranthikumar/biography

majumdarshiv's picture

majumdarshiv

Thu, 12/24/2009 - 07:52

Dear Kranthi,

Thanks for the words

Regards
Shiv

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zarrinfaria's picture

zarrinfaria

Thu, 12/24/2009 - 18:23

Dear sir..
A great blog...thank for reminding again the potency of the great molecules that was discovered ages ago and that has been revived and still in demand...
Regards,
Faria Zarrin
Team: BLOGBUSTERS

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majumdarshiv's picture

majumdarshiv

Mon, 01/04/2010 - 04:15

Dear Faria,

Yes Aspirin is supposed to be one of the oldest drug that is discovered, but still in use. This blog highlights few interesting & new aspects of that older drug.

Regards
Shiv

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udayasree datla's picture

udayasree datla

Sat, 12/26/2009 - 05:41

Hai sir,
Really aspirin has many therapeutic uses. And I heard that minoxidil is used in the treatment of pattern baldness in males (due to its property of hypertrichosis).

Regards, UDAYASREE DATLA. http://www.pharmainfo.net/udayasree-datla/biography
majumdarshiv's picture

majumdarshiv

Mon, 01/04/2010 - 04:13

Dear Udaysree,

Thanks for the comment. Yeah Minoxidil is used in Patterened Baldness (I gave reply to Manthan also, check the other comments) Its a side effect of that drug that is modified in terms of its therapeutic effect.

Regards
Shiv

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