Old Drug but New Use
The most rational basis for the discovery of a new drug is to start with an old drug. If we consider compounds that have been discontinued in the market for reasons other than safety, it reasonably makes sense to look at failed compounds first when identifying new chemical entities to satisfy unmet medical need. After all, these have already been proven to be safe, just not effective in the original indication
ASPIRIN-Over 100 years ago, aspirin became the first drug to be made synthetically, and its marketing laid the foundation of the modern pharmaceutical industry. It is still the benchmark against which other analgesics are measured. The new uses of aspirin are
Dementia A reduction in cognitive decline and dementia in patients who take aspirin has been suggested. If confirmed, this will be of enormous importance to public health. Lesser degrees of damage from vascular lesions may also be prevented by low-dose aspirin. Evidences from a number of trials are urgently needed but results from one trial have already suggested benefit.
Another form of dementia is Alzheimer's disease. A large number of studies have shown a reduced incidence of Alzheimer's disease in patients taking aspirin or other anti-inflammatory drugs
Cataracts An association between regular aspirin use and reduced development of cataract has been reported.
In coming blogs, I'll discuss few such examples