Maximizing Outsourced Biopharma Production

The rationale for sustained/ controlled drug delivery is to alter the pharmacokinetic and pharmacodynamic of pharmacologically active moieties by using novel drug delivery systems or by modifying the molecular structure and/ or physiological parameters inherent to a selected route of administration. It is desirable that the duration of drug action become more a design properly of a rate controlled dosage form, and less, or not at all, a property of drug molecule’s inherent kinetic properties. As mentioned earlier, the primary objectives of sustained/controlled drug delivery are to ensure safety and to improve efficacy of drugs as well as patient compliance. This is achieved by better control of plasma drug levels and less frequent dosing.