MAOA inhibitors-mechanism of action

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MAOA inhibitors-mechanism of action

1.Monoamine oxidase A called as MAOA is an enzyme that is involved in metabolism of monoamines, for example: 5-HT and noradrenaline.(1)

2.Itconverts the monoamines to their corresponding carboxylic acid forming analdehyde as an intermediate.(1)

MAOA regulates both free intraneuronal concentration and also the releasable stores of 5-HT and noradrenaline.(1)

3.MAOA inhibitors, like phenelzine, bind and inhibit MAOA, and prevent the monoamine degradation. This results in the greater stores of the monoamines available for the release.(2)

4. MAOA
inhibitors are used in treatment of depression. People with depression will
have lower than normal levels of monoamines and MAOA inhibitors will restore
the levels to the normal range.
(2)

MECHANISM(3)

MECHANISM

REFERENCES:

1.Noradrenergic transmission. In: Pharmacology, 4th edition. Rang HP, Dale MM and Ritter JM. Edinburgh, UK:
Harcourt Publishers Ltd, 2001:139-163.

2.Drugs used in affective disorders. In: Pharmacology, 4th edition. Rang HP, Dale MM and Ritter JM. Edinburgh, UK: Harcourt Publishers Ltd, 2001:550-565.

3.http://www.cnsforum.com/imagebank/item/Drug_MOAI_2/default.aspx(ACCESSED ON 8TH OCT,11:24 A.M)

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Sirisha Pingali's picture

Great presentation sandhya. It is clear and lucid. Keep going!!

Sirisha Pingali

http://www.pharmainfo.net/sirisha

Viswanadha Institute of Pharmaceutical Sciences.

www.vnips.edu.in

Sandhya Sravya malla's picture

thank u very much.......happy blogging m.sandhyasravya@gmail.com pharma warriors
Shouvik's picture

madam pls explain the answer for this question........................why mao inhibitors are useful in treating both depression as well as parkinsonism..???????????????????????

$houvik

Sandhya Sravya malla's picture

1.Monoamine oxidase B (MAOB):It is an enzyme involved in the metabolism of the dopamine. It will convert dopamine to its corresponding carboxylic acid through an aldehyde intermediate. MAOB regulates both free intraneuronal concentration of dopamine and also the releasable stores. MAOB inhibitors, like selegiline, bind to and inhibits MAOB, preventing the degradation of dopamine. This will result in greater stores of dopamine which is available for release. Even these are used to treat depression. (http://www.cnsforum.com/content/pictures/imagebank/lorespng/MAOB_inhib.png) 2.MAOA inhibitors will restore the levels of dopamine in case of low levels hence used in treatment of depression. 3. it provides the neuroprotection, by reflecting possibility of slowing, halting and maybe also reversing, neurodegeneration in Parkinson's disease.hence used in this case... m.sandhyasravya PHARMA WARRIORS

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