MAOA inhibitors-mechanism of action
1.Monoamine oxidase A called as MAOA is an enzyme that is involved in metabolism of monoamines, for example: 5-HT and noradrenaline.(1)
2.Itconverts the monoamines to their corresponding carboxylic acid forming analdehyde as an intermediate.(1)
MAOA regulates both free intraneuronal concentration and also the releasable stores of 5-HT and noradrenaline.(1)
3.MAOA inhibitors, like phenelzine, bind and inhibit MAOA, and prevent the monoamine degradation. This results in the greater stores of the monoamines available for the release.(2)
inhibitors are used in treatment of depression. People with depression will
have lower than normal levels of monoamines and MAOA inhibitors will restore
the levels to the normal range.(2)
1.Noradrenergic transmission. In: Pharmacology, 4th edition. Rang HP, Dale MM and Ritter JM. Edinburgh, UK:
Harcourt Publishers Ltd, 2001:139-163.
2.Drugs used in affective disorders. In: Pharmacology, 4th edition. Rang HP, Dale MM and Ritter JM. Edinburgh, UK: Harcourt Publishers Ltd, 2001:550-565.
3.http://www.cnsforum.com/imagebank/item/Drug_MOAI_2/default.aspx(ACCESSED ON 8TH OCT,11:24 A.M)
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