Bioassay-Guided Isolation of Epiquinamide, a Novel Quinolizidine Alkaloid

The screening of crude natural product extracts and combinatorial libraries for activities has been a major source of biologically active compounds for drug development efforts. However, whole extract screens can be problematic when multiple, potentially interfering activities or nonspecifically active compounds, such as tannins or leptins, are present. The ability to separate and assess individually such activities without macroscopic isolation represents an extremely useful method for drug discovery.

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