Occurrence and Significance of Decahydroquinolines from Dendrobatid Poison Frogs

2,5-Disubstituted decahydroquinolines (DHQs) represent o­ne of the major classes of amphibian alkaloids. They have been detected in skin extracts of dendrobatid and mantelline frogs and bufonid toads, and for 5-epi-cis-275B' (16) and 5-epi-trans-275B (17) found in the extracts of virgin queens of a myrmicine ant. Detection of such DHQs in an ant, their first reported occurrence, strengthens a dietary hypothesis for the origin of the approximately 30 DHQs that have been detected in extracts of frog skin.

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