From all what we have discussed on the BBB and its functioning,we can consider three important strategies to overcome the hurdles set up by BBB.They may be simply put as:

It is a known fact that highly lipid soluble compounds like barbiturates easily cross the BBB. Also certain non-lipophillic micro molecules as well as macromolecules cross the BBB. The transport of such molecules takes place by one of the three processes:

* Bulk-phase endocytosis

* Absorptive endocytosis &

* Receptor-mediated endocytosis.

Absorptive endocytosis takes place by the alteration of charges and development of opposite charges on the substance and the cell membrane molecules. An example of such transport is the Wheat Germ Agglutinin (WGA).

Consider the Parliment house; it is the centre of decision making of our nation. It is very well protected by a large security force. Although all the major roads lead to it, no one can enter it without proper identification and only a limited number of persons are given access to it.

Mr. Dean Kamen is a well known scientist who is best known for his Segway PT (a mobility device). His other inventions include an all terrain wheel chair, water purifier system, the first insulin pump etc.

The patient is the end consumer in the drug market. He buys the products on prescription by medical practitioners or buys over the counter products (OTC).

The doctor is an integral part of the healthcare system. He is the professional authority who diagnoses and prescribes drugs to the patients. In a manner of speaking, he "directs" the consumer (patient) of the drug market to buy a product of "his liking".

A retailer is the terminal part of the supply chain hierarchy. He is the one who sells the products to the consumer (patient). A retailer buys the stocks from the wholesaler or stockist and sells them in retail. He holds a licence to sell, display and deliver drugs from either a permanent establishment called retail pharmacy store/drug store or he may also sell by delivering products to the consumer directly called as itinerant pharmacy (hawkers, peddlers, street traders etc).