Tablet Relaxation and Physiocomechanical Stability of Lactose, Microcrystalline Cellulose, and Dibas

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Tablet Relaxation and Physiocomechanical Stability of Lactose, Microcrystalline Cellulose, and Dibasic Calcuim Phosphate01

Tablets are the most popular dosage form of pharmaceutical products. A typical tablet formulation consists of the active pharmaceutical ingredient(s) (API), filler(s), disintegrant, lubricant, and other inactive ingredients (e.g., binder, glidant, and colorant). A formulation scientist must conduct a thorough study both to optimize a formulation so that it meets all specifications and to ensure safety and efficacy. The specifications for pharmaceutical tablets usually include appearance, weight, thickness, hardness, friability, disintegration, dissolution, content uniformity, assay, organoleptic characteristics, and other product-specific requirements. These specifications are established to ensure that the tablets will have sufficient mechanical strength to withstand packaging, shipping, and handling and are physically and chemically stable to deliver the accurate amount of drug at the desired dissolution rate when consumed by a patient.Any changes in these characteristics may significantly affect the safety and efficacy of the product.

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