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The patient was administered with four doses of Calando’s CALAA-01, a targeted siRNA nanoparticle, over a two week period.

This development is another milestone for siRNA technology, which many people have high hopes for in the treatment of a diverse range of illnesses.

The siRNA was delivered using Calando's Rondel delivery technology, which the company describes as a "three-part RNAi /Oligonucleotide Nanoparticle Delivery technology".

This entails a polymer binding along the length of the siRNA, with the resulting complex self-assembling into nanoparticles less than 100nm in diameter. This process serves to protect the siRNA from nuclease degradation.

In addition, a molecule in the polymer called cyclodextrin facilitates the attachment of stabilizing agents and targeting ligands to the surface of the siRNA/polymer complex.