Floating Tablet

Sponsored Links

Floating tablets are retained in the stomach and are useful for drugs that are poorly soluble or unstable in intestinal fluids. The underlying principle is very simple. One attempts to make the dosage form less dense than the gastric fluids so that it can float on them by incorporating a number of low density fillers into the systems such as hydroxyl cellulose, lactates or microcrystalline cellulose. They also have an advantage over the conventional system as it can be used to overcome the adversities of gastric retention time as well as the gastric emptying time. These types of tablets are especially very useful in the treatment of the disorders related to the stomach. All those molecules with considerably short half life can be administered in this manner to get an appreciable therapeutic activity. Drugs that have poor bioavailability because of site-specific absorption from the upper part of the gastrointestinal tract are potential candidates to be formulated as floating drug delivery systems, thereby maximizing their absorption.

Click to see next slide

[swf file="pppc02/KhushbuPatel.swf"]

Information Zone: 

Comments

Anuja Raut's picture

Dear Khushbu.. Can the mechanism of matrix tablets be employed in floating tablets? So that drugs that have poor bioavailability because of site-specific absorption also have a sustained release?

Khushbu Hasmukh Patel's picture

These are matrix types of systems prepared with the help of swellable polymers such as methylcellulose and chitosan and various effervescent compounds, eg, sodium bicarbonate, tartaric acid, and citric acid. They are formulated in such a way that when in contact with the acidic gastric contents, CO2 is liberated and gets entrapped in swollen hydrocolloids, which provides buoyancy to the dosage forms.

K.H.Patel.
My profile link is
http://www.pharmainfo.net/khushbu-hasmukh-patel

Ankit's picture

Dear Khushbu..
nice presentation
can you say me about ideal gastric transit time for sustain release formulation using FDDS.
here what should be the ideal HLB values and density of polymer to float in gastric region?
can you suggest me some other polymers used in FDDS and also various grades of cellullose?
and what should be the specific evaluation parameters used for this system?
thanking you.

Khushbu Hasmukh Patel's picture

hello

High viscosity grade polymers givs best fdds

Some eg.

HPMC K4 M), Calcium alginate, Eudragit S100, Eudragit RL, Propylene foam, Eudragit RS, ethyl cellulose, poly methyl meth acrylate, Methocel K4M, Polyethylene oxide, β Cyclodextrin, HPMC 4000, HPMC 100,CMC, Polyethylene glycol, polycarbonate, PVA, HPC-L, Metolose S.M. 100, Carbopol

K.H.Patel.
My profile link is
http://www.pharmainfo.net/khushbu-hasmukh-patel

Jigard Patel's picture

Dear Khushbu;
Nice presentation;
Describe the effect of bowel movement and gastic secretion on release of drug from floating tablet...

Khushbu Hasmukh Patel's picture

hi nice ques.

gastric emptying rates revealed that orally administered controlled release dosage forms are subjected to basically 2 complications, that of short gastric residence time and unpredictable gastric emptying rate.
Gastric residence time of an oral dosage form is affected by several factors. To pass through the pyloric valve into the small intestine the particle size should be in the range of 1 to 2 mm.15 The pH of the stomach in fasting state is ~1.5 to 2.0 and in fed state is 2.0 to 6.0. A large volume of water administered with an oral dosage form raises the pH of stomach contents to 6.0 to 9.0. Stomach doesn’t get time to produce sufficient acid when the liquid empties the stomach, hence generally basic drugs have a better chance of dissolving in fed state than in a fasting state.

The use of large single-unit dosage forms sometimes poses a problem of permanent retention of rigid large-sized single-unit forms especially in patients with bowel obstruction, intestinal adhesion, gastropathy, or a narrow pyloric opening (mean resting pyloric diameter 12.8 ± 7.0 mm). Floating dosage form should not be given to a patient just before going to bed as the gastric emptying of such a dosage form occurs randomly when the subject is in supine posture.

K.H.Patel.
My profile link is
http://www.pharmainfo.net/khushbu-hasmukh-patel

Hrushikesh Karandikar's picture

hellow Khushbu

Could you pls tel me if u have given NSAID's drug which is having ulcerogenic property and you cant change the drug as it is imp as a pain killer then how your Flotting tablet will be option to control the gastric irritation just bcz of NSAID's.

Thanks.
hrushikesh

Khushbu Hasmukh Patel's picture

hi, nice ques.
Asprin is available as FDDs.
Floting drug delivery system mainly used for controlled relase and when the dose is large .
While taking NSAID's with drug take large volume of water which shift gastric ph towards neutral value .

K.H.Patel.
My profile link is
http://www.pharmainfo.net/khushbu-hasmukh-patel

Ayush Singhal's picture

1)what are the disadvantges of this FDDS?

2)is there chances of developing bloating or flatulence in case of effervescent systems?if no why?

3)suggest some measure to remove if above problem exists.

thank you.....

Ayush A. Singhal RPCP, CHANGA GUJARAT http://www.pharmainfo.net/ayushsinghal/biography

Khushbu Hasmukh Patel's picture

According to me there is no chances of developing bloating or flatulence in case of effervescent if you take proper precaution while developing dosage form . Further explaination is as follows-
These are matrix types of systems prepared with the help of swellable polymers such as methylcellulose and chitosan and various effervescent compounds, eg, sodium bicarbonate, tartaric acid, and citric acid. They are formulated in such a way that when in contact with the acidic gastric contents, CO2 is liberated and gets entrapped in swollen hydrocolloids, which provides buoyancy to the dosage forms.

K.H.Patel.
My profile link is
http://www.pharmainfo.net/khushbu-hasmukh-patel

Ganesh Nirma's picture

hi khushbu,

its a nice presentation.

Is the floating tablet more efficient than Floating microsphere?if yes than in which sense??

Regards
Ganesh

Khushbu Hasmukh Patel's picture

tanks for ques.Microspheres have high loading capacity and many polymers have been used such as albumin, gelatin, starch, polymethacrylate, polyacrylamine, and polyalkylcyanoacrylate. Spherical polymeric microsponges, also referred to as “microballoons,” have been prepared. Microspheres have a characteristic internal hollow structure and show an excellent in vitro floatability.27

Single-unit formulations are associated with problems such as sticking together or being obstructed in the gastrointestinal tract, which may have a potential danger of producing irritation. this type of problem can be overcome by microsphere

K.H.Patel.
My profile link is
http://www.pharmainfo.net/khushbu-hasmukh-patel

Ganesh Nirma's picture

hi khushbu,

Can i also ask that how the compression granulation advantageous over wet granulation??

Regards
ganesh.

Khushbu Hasmukh Patel's picture

We cant compare this both metods , it will depend upon charecterstic of drug and compatability of drug with other ingredients .
Direct compression is time saving method over the wet granulation.
It bypass following steps of wet granulation......
Step 2: The wet granulate is prepared by adding the liquid binder/adhesive.
Step 3: Screening the damp mass into pellets or granules
Step 4: Drying the granulation
Step 5: Dry screening:

K.H.Patel.
My profile link is
http://www.pharmainfo.net/khushbu-hasmukh-patel

Lakshmi's picture

Dear Khushbu,

What are the disadvantages of single unit dosage forms that are overcome by multiple unit dosage forms?

Khushbu Hasmukh Patel's picture

Single-unit formulations are associated with problems such as sticking together or being obstructed in the gastrointestinal tract, which may have a potential danger of producing irritation. this type of problem can be overcome by multiple unit dosage forms

K.H.Patel.
My profile link is
http://www.pharmainfo.net/khushbu-hasmukh-patel

Ankit Sheela Mittal's picture

hi.
pls tell me Preparation and characterization of chitosan nanoparticles for nose to brain delivery of a cholinesterase inhibitor ?
Thanks
MITTAL

K.Swapna's picture

which drugs are suitable for floating tablets.

K.s

Prashant Khemariya's picture

those that having absorption on upper part of stomach. Regards Prashant Khemariya Research Scientist R&D, NDDS 09172689306

Prashant Khemariya Mumbai Mumbai +919172689306

Bhasker Reddy's picture

nice presentation how much time these floating tablets can be retained in the stomach? what class of drugs are best suitable for this type of delivery?

D.BASKER REDDY

Kamanashis Das's picture

Thanx for ur nice presentation. Please, can you tell me the formulation of floating tablet?
Srinivas Dharam's picture

Hi khushbu could you please tell me what kind of drugs can be formulated into floating tablets?  in comparison to pharmacokinetic profile, like bio availability, protein binding etc..