Floating tablets are retained in the stomach and are useful for drugs that are poorly soluble or unstable in intestinal fluids. The underlying principle is very simple. One attempts to make the dosage form less dense than the gastric fluids so that it can float on them by incorporating a number of low density fillers into the systems such as hydroxyl cellulose, lactates or microcrystalline cellulose. They also have an advantage over the conventional system as it can be used to overcome the adversities of gastric retention time as well as the gastric emptying time. These types of tablets are especially very useful in the treatment of the disorders related to the stomach. All those molecules with considerably short half life can be administered in this manner to get an appreciable therapeutic activity. Drugs that have poor bioavailability because of site-specific absorption from the upper part of the gastrointestinal tract are potential candidates to be formulated as floating drug delivery systems, thereby maximizing their absorption.
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