Gold Nanoparticles : A Novel Biological Approach to Target Hiv And Hiv-Associated Opportunistic Infections for Women

Submitted by V. SATYA VENI on Thu, 09/10/2009 - 22:34

Globally, there were an estimated 33 million people living with HIV in 2007. In special consideration to women in India, account for around one million out of 2.5 million estimated number of people living with HIV/AIDS. Their heightened vulnerability has both biological and socio-economic reasons. Early marriage, violence and sexual abuse against women are the major socio-economic reasons of their vulnerability to HIV infection. Their biological construct makes them more susceptible to HIV infection in any given heterosexual encounter. HIV positive women are at a greater risk of depression than man, and HIV positive women with major depression go to their medical visits with less regularity, is less adherent to their treatment, have infections more likely to progress quickly to AIDS and have higher mortality rate. The present study focus on the rise of HIV and HIV-associated Opportunistic Infection (OI) in women, it is important to understand their struggles and unique issues. Moreover, study provides scope of biologically synthesized eco-friendly gold nanoparticle, incorporation of gold nanoparticles in cotton and drug-gold nanoparticle conjugates that targets HIV/HIV associated OI in women.

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Comments

majumdarshiv's picture

majumdarshiv

Sat, 09/12/2009 - 04:45

Dear Mam,

Seems to be quite unusual & interesting topic. My question is why Gold is chosen for this? is there any specific mechanism or evidence that it has role in HIV? Other than Gold what can be prefered?

Regards
Shiv

My Team :
http://www.pharmainfo.net/blog/team-infinity

My Page :
http://www.pharmainfo.net/majumdarshiv/biography

V. SATYA VENI's picture

V. SATYA VENI

Sat, 09/12/2009 - 07:28

Dear sir

Here i have submitted the biologically synthesized gold nanoparicles by using micro organism. we have an evidence for biological synthesis of these kind of metal nanoparicles and its anti bacterial , viral activity.We can prefer silver also.

While developing eco-friendly nanoparticles synthesis with out using any toxic chemicals in the protocol, synthesis will be very slower rate as compared to chemical process and synthesized metals doesnot posses stability also.

But Gold nanoparticles can synthesis very rapidly with good stabilty in our normal laboratory itself at low cost.

majumdarshiv's picture

majumdarshiv

Mon, 09/14/2009 - 10:29

Dear Mam,

Really as I said earlier a unique topic that you select & moreover you explained queries properly. Thanks for the answer, best of luck.

regards
shiv

My Team :
http://www.pharmainfo.net/blog/team-infinity

My Page :
http://www.pharmainfo.net/majumdarshiv/biography

V. SATYA VENI's picture

V. SATYA VENI

Mon, 09/14/2009 - 15:48

Dear Mr.Shiv

Thank you very much for your best wishes sir.

Regards

V.Satya veni

rujuta_mehendale's picture

rujuta_mehendale

Sat, 09/12/2009 - 18:47

Good presentation and a very good topic indeed!
Im very much impressed by its current social relevance. It is indeed necessary to work on improving the AIDS prevalence among women considering the double standards between men and women, still rampant in India.

However i would like to know in detail about the eco-friendly status of these gold nanoparticles. Is there any specific research work done to prove its eco-friendliness?

V. SATYA VENI's picture

V. SATYA VENI

Sun, 09/13/2009 - 14:02

Dear Rujuta mahendale

Thank you very much for your nice complement. Here I am synthesizing gold nanoparticles by using micro organisms biologically without Addition of any chemical and synthetic protocol.

There are several reports for eco-friendly nanoparticle synthesis. My guide has done this work and published the paper also.

aparna's picture

aparna

Sun, 09/13/2009 - 04:34

is it marketed? or under clinical trials? is it economical to indians? can we use it in serious HIV infections? should it be used along with other treatments? how it is going to act on the specific site?

http://www.pharmainfo.net/aparna

V. SATYA VENI's picture

V. SATYA VENI

Sun, 09/13/2009 - 07:39

No gold nanoparticles are available in the market for the treatment of HIV/HIV associated OI infections and not in clinical trials also.These are entirely new approach and its very economical to Indians because we can synthesis these nanoparticles in normal laboratory scale itself.

You might be known about secondary infections is the last stage during HIV, we can use these nanoparicles mainly for OI infections.

we can use along with other infections also for example Bacterial vaginosis (BV) is the most common cause of vaginal infection. BV is caused by an imbalance of naturally occurring bacterial flora due to cosmetic wash in vagina.Development of gold nanoparticle vaginal cream would be good alternative.

There are three types of antimicrobial mechanism were observed Plasmolysis , cytoplasm of bacteria separated from cell wall and inhibition of cell wall synthesis. Incase of HIV , the anti-viral activity were proved by measuring P24 antigen production and reduse of apoptosis.

Lakshmi's picture

Lakshmi

Sun, 09/20/2009 - 11:00

Dear Mam,
A very good topic.. In your presentation you have mentioned that expensive treatment is a major challenge in treating HIV infections. But synthesis of gold nanoparticles requires sophisticated technology which is also very expensive. Are there any means to make them economical.
These nanoparticles as you have discussed would surely be effective in treating secondary infections but can these gold nanoparticles prevent the further occurance of same or a different infection? How could these contribute to the treatment or prophylaxis of HIV primary infection?

V. SATYA VENI's picture

V. SATYA VENI

Fri, 10/02/2009 - 09:31

Dear Lakshmi

Thank you for your comments

FDor synthesis of gold nanoparticles, no need of shophisticated technology and costly lab and you can do synthesis in your normal lab itself.

If you are delivering these metal nano particles by vaginal route difinetly it wil helful for womens health.

it wil prevent the viral synthesis by destroying the cell wall and it wil prevent the multiplication of microbes.

devanshi's picture

devanshi

Mon, 09/21/2009 - 15:19

A nice topic indeed but i would really like to know since your presentation is mainly based on gold nanoparticles but there are lots of other nanoparticles such as nanocrystals etc. do you think they are equally efficient for opportunistic infections

V. SATYA VENI's picture

V. SATYA VENI

Fri, 10/02/2009 - 09:36

Dear devanshi

You might be know most of the metals posses antimicrobial properties. So other metal nanoparicles also having the great scope for the traetment of HIV and its OI.

anuja raut's picture

anuja raut

Fri, 09/25/2009 - 16:36

Dear Ma'am, yours is a very novel and impressive topic.

I would like to know what factors make gold nanoparticles ecofriendly? explain. And are they affordable to common masses as the synthesis technoogy must be expensive.

Thanks

V. SATYA VENI's picture

V. SATYA VENI

Fri, 10/02/2009 - 09:41

Dear anuja

Here i am presented the biological synthesis of metal nanoparticles without using any toxic chemicals and toxic chemical protocals and with low cost we can do synthesis.

santosh kumar. JH's picture

santosh kumar. JH

Sat, 09/26/2009 - 05:43

Really a nice presentation...

You had mentioned about drug conjugated metal nanoparticle for targeted delivery is their any study regarding this.. if possible can you explain me which drug molecules can be conjugated with metal nanoparticles ?

Regards,
Santosh Kumar
www.pharmainfo.net/santosh-kumar-jh

Regards, Santosh Kumar http://www.pharmainfo.net/santosh-kumar-jh
V. SATYA VENI's picture

V. SATYA VENI

Fri, 10/02/2009 - 09:47

Dear Santhosh

We have so much evidence for drug conjucated metal nanoparticles.

For Example
We have antibiotics for treatment of microbial infections but now a days microbs got resistence againnt that antibiotics.So we can go with Antibiotic- conjucated metal nanoparticles for imporve tyhe efficacy of that drug.

Hrushikesh Karandikar's picture

Hrushikesh Kara...

Sat, 09/26/2009 - 06:19

good topic

Could you pls tel me how these conjugation with metal could help?

Whether this conjugation is physical or chemical??

V. SATYA VENI's picture

V. SATYA VENI

Sat, 10/03/2009 - 12:13

Dear Hrushikesh Kara

we can conjugate any drug with gold nanoparticles.Drug can be directly bound onto AuNP via the functional group like carboxyl group (-COOH) to form the Drug-AuNP complex and kinetically released from the nanoparticles.

ayushsinghal's picture

ayushsinghal

Sun, 09/27/2009 - 06:01

Miss. V.Satya,

1)As you mentioned that the gold nano-particles can improve the efficacy of drug therapy can these be effective in drug resistant patients too?

2)if yes please give some idea or concept how these wont be affected by the problem of drug resistance?

thank you....

Ayush A. Singhal RPCP, CHANGA GUJARAT http://www.pharmainfo.net/ayushsinghal/biography
V. SATYA VENI's picture

V. SATYA VENI

Sat, 10/03/2009 - 12:24

Dear Ayush A. Singhal

Yes sir It can be very effective for such patients.
You know very well about drug resistence, These metal nano particles naturally having potent anti microbial activity, definetly in future it serves as a new generation antimicrobial agents.
Moreover, we can conjugate these metal nanoparticles with drug and some surgical dressings.

shilpa.sambana's picture

shilpa.sambana

Sun, 09/27/2009 - 06:33

Good presentation,I have found your presentation mostly concentrated on women,and you have provided the conjugation of gold nanoparticles to enhace the efficacy of HIV treatment in view of women only.

But why cant this gold nanoparticles be used to tmen also to increase their efficacy of treatment.

One more thing , i found your presentation more of statistics than the action of these gold nanopartiocles. Other wise its good

regards,

shilpa.s

shilpa.sambana st Ann's college of pharmacy
V. SATYA VENI's picture

V. SATYA VENI

Sat, 10/03/2009 - 12:30

Dear SHILPA.SAMBANA

Thank you very much for your precise comments mam

Sure, we can use for men also but as compared men, Women are mostly affected due to so much of socio- economical and other reasons.

devanshi's picture

devanshi

Sun, 09/27/2009 - 15:52

Ur topic mainly focuses on gold nanoparticles however,there are a lot other nanoparticles such as nanocrystals and nanotubes do you think they are equally efficient?

V. SATYA VENI's picture

V. SATYA VENI

Sat, 10/03/2009 - 12:34

Dear devanshi

Great mam,
According to my view Such normal nano meter sized crystals or tubes are not useful .

kiran_mandlem's picture

kiran_mandlem

Mon, 09/28/2009 - 08:36

you have discuussed about more on ststistics and more of the symptoms of AIDS in women rather than formulation of gold nanoparticles. Is it currently practising and how far it is suggestable along with other types of treatment for AIDS

Kiran
My Page Link : http://www.pharmainfo.net/kiranmandlem

V. SATYA VENI's picture

V. SATYA VENI

Sat, 10/03/2009 - 12:41

Dear Kiran Mandlem

Thank you sir

Its not in current practice
and we have so much of evidence for anti- HIV activity of metal nanoparticles.Surely it can serve as great formulation in future

apurva.anugamini's picture

apurva.anugamini

Mon, 09/28/2009 - 14:40

hello madam,
i just wanted to ask that why have you emphasises on only women curing..
cant this gold nano particle be used for curing that same in men from HIV??

V. SATYA VENI's picture

V. SATYA VENI

Sat, 10/03/2009 - 12:43

Dear Apurva Anugamini

Sure, we can use for men also but as compared men, Women are mostly affected due to so much of socio- economical and other reasons.
Thank you

chitrakaladhuri's picture

chitrakaladhuri

Wed, 09/30/2009 - 01:02

A nice presentation but you have emphasized more on the social state then the pharmaceutical approach of using the gold particle..
So can you please give some details on the method of using this technology.
Mention where this technology has been already used & its success status.
Name few marketed products.
And you mentioned that these gold nanoparticles can be used in cotton & hence be used..but that would result in rise in the cost of those commodities & may make it more diificult to be accessed by the deprived.

ks kumar upadhyayula's picture

ks kumar upadhyayula

Thu, 10/01/2009 - 21:03

Dear Satyaveni,

How far are these gold nanoparticles successful in treatment of HIV and are there any evidences? Does this have any other methods of preventing such as morally supporting women or by providing education?Please clarify.

Regards,
K.S.Kumar Upadhyayula.

http://www.pharmainfo.net/ks-kumar-upadhyayula

abherids86's picture

abherids86

Fri, 10/02/2009 - 07:14

Hello Madam,

Good presentation...
Can particle clearance be altered by altering particle size?
What are the basic mechanisms by which proteins or drugs bind to colloidal gold nanoparticles?

Thank you.

ABHERI DAS SARMA
http://www.pharmainfo.net/abherids86

anis0019's picture

anis0019

Fri, 10/02/2009 - 14:16

Hi Satyaveni,

Good Presentation.
a) Gold nanoparticles are taken up by RES so what are the measures to prevent this?
b) How does surface charge of gold nanoparticles influence the bioavailability of the targeted using gold nanoparticles?

Thank You.

Priyanka D. Chauhan's picture

Priyanka D. Chauhan

Sat, 10/03/2009 - 07:38

Miss Satya veni,
Impressive presentation.
what are the toxicity issues relating to gold nanoparticles?
Are drugs containing gold nanoparticles cost effective? If no,then how do you propose to reduce the high cost so as to make the drugs affordable to a larger population?

priyanka

kavita_a_iyer's picture

kavita_a_iyer

Sat, 10/03/2009 - 08:14

Ms. Satya veni,

A very innovative topic.

1. Is this technology still under investgation or has any product been released in the market? If yes, kindly name a few.
2. Also what is the pharmacokinetic profile of such gold nanoparticles and the toxcity associated with them?

Kavita Iyer

Reena Chaudhary's picture

Reena Chaudhary

Sun, 10/04/2009 - 06:32

Good presentation.
I would like to know how cost-effective would this technology be?
Also,is this being used anywhere currently?

komal nikam's picture

komal nikam

Sun, 10/04/2009 - 14:20

Dear Mam,
What care should be taken while formulating nanoparticles since they are very small in size?

Komal Nikam
http://www.pharmainfo.net/komal-nikam

komal nikam's picture

komal nikam

Sun, 10/04/2009 - 14:23

Dear Mam,
What about the stability & toxicity of gold nanoparticles?

Komal Nikam
http://www.pharmainfo.net/komal-nikam

ankitsheelamittal's picture

ankitsheelamittal

Sun, 10/04/2009 - 17:14

PLS MENTION SOME OF DEVICES USED IN THE SAME ?
THANKS
MITTAL

shanthi priya's picture

shanthi priya

Sun, 10/04/2009 - 20:34

Are these products with Gold Nanoparticles are available in the market ???

thank you

shanthi priya

Shanthi priya

ayushsinghal's picture

ayushsinghal

Mon, 10/05/2009 - 15:04

Sorry mam to say this but haven't got a satisfactory answer to my question.

thank you....

Ayush A. Singhal RPCP, CHANGA GUJARAT http://www.pharmainfo.net/ayushsinghal/biography