Needle Free Injection Technology

Submitted by madhuri on Mon, 02/09/2009 - 20:05

The demand for novel drug delivery technologies is ever increasing. Drug delivery technologies can be classified as Oral, Parenteral, inhalation and transdermal. Needle-Free injection technology offers the very obvious benefit of reducing patient concern about the use of needle.

Drug delivery through oral route is the more convenient and versatile one. It is not possible to deliver some of the protein-based drugs through this method. For example, insulin, growth hormone, biologics can’t be delivered by this route.

The newly introduced technology which is in market for the last few years that acts as remedy for the patients like diabetics who need to take injection regularly and even for the infants is Needle free injection technology. This technology is emerging as a major sector within the drug delivery industry.

It works by forcing liquid medication at high speed through a tiny orifice that is held against the skin. This creates an ultra-fine stream of high pressure fluid that penetrates the skin without the use of needle. There are few professional grade injection systems also like Bijector 2000, Vitajet3, coolclick, Seroject, Iject etc.

Needle-free injections are being well supported by organizations like WHO and CDC (Centre for Disease Control). It became more feasible technology for injecting the protein-based drugs especially monoclonal antibodies (MABS).

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Comments

kanaka kumari

Fri, 02/13/2009 - 10:41

hi madhuri,
your ppt is simple and outstanding. you have mentioned about all the needle free injections and thier uses in a well manner. but you have given that this technology can be used for solid dosage forms, so can u give some examples and a brief explanation?

kanaka
kranthikumar's picture

kranthikumar

Fri, 02/13/2009 - 13:50

Dear Madhuri,
I appreciate you presentation. But can you give me the following information,
1 As you mentioned in bio values its the only needle free injections that deliver drugs to intra muscular.... deponding on clinical need. what do you mean by "Deponding on clinical need."
2 YOU have mentioned that excess pressure will damage the products like Monoclonal antibodies etc. Then how are they delivered through needle free injection. If its used with less pressure, then how will it gets injected into the Body. and what is the optimun pressure that you should use?
3 Finally You have just mentioned the advantages of Needle free injection. Does not it carry any disadvantages? other than cost.
Kranthi

Regards Kranthi http://www.pharmainfo.net/kranthikumar/biography

pharmacistdixon's picture

pharmacistdixon

Fri, 02/13/2009 - 14:25

good job
DIXON THOMAS
MDCP, BELA POST
KERALA, INDIA 671321
http://www.pharmainfo.net/pharmacistdixon

Mr. Dixon Thomas, M. Pharm, M. S., RPh Assoc. Prof., RIPER
harrybasson's picture

harrybasson

Sat, 02/14/2009 - 03:58

Your ppt is good , But u have not mentioned clearly about varius drugs in which this system can be used except insulin and hormones , is it possible to deliver other powder drugs as in case of antibiotics by dissolving in varous solvent or other drugs??????????

madhuri's picture

madhuri

Thu, 02/19/2009 - 12:49

yes it can be used for other types of drugs other than insulin and harmones. but in liquid form injection is getting wasted and it is not reaching the blood circulation. so it is one of the drawback. thank u for sending comment.

madhuri
pulkit_kadam's picture

pulkit_kadam

Sat, 02/14/2009 - 20:41

your presentation is good but this was done since 8 years ago . But this injection is totally wasted when liq. dosage is admisnistered intravenously . If it is being used injecting on direct blood plasma it works. But without the contact of veins with needle one cannot administer drugs via needle less injections when the drugs required in veins .Think and checkout.

rashmipatil's picture

rashmipatil

Sun, 02/15/2009 - 03:53

i agree with pulkit ! the injection is of no use when liquid dosage is administered intravenously

madhuri's picture

madhuri

Sun, 02/15/2009 - 07:33

yes i agree with u. when liquid dosage forms are injected it is getting wasted but it is also useful in injecting solid dosage forms. it is of great use in case of diabetes care and harmonal injectables every day. so i think it will be useful to us at a great extent.thank u.

madhuri
pulkit_kadam's picture

pulkit_kadam

Sun, 02/15/2009 - 09:32

you are saying that it could be applicable for insulin injection. but these injection are to much costly to use and it wont reach to every class of society and in gov. hospitals it wont pass either. thanks

madhuri's picture

madhuri

Thu, 02/19/2009 - 12:56

i agree with in this view that about its cost. besides cost it is some wat in use.to over come this drawback the economic crisis should be reduced. the pharma companies which are producing these needle free injections should try to reduce their cost as much as possible.if it overcomes this drawback then it will be of great use to people.thank u.

madhuri
shilpa.sambana's picture

shilpa.sambana

Sun, 02/15/2009 - 05:40

hi madhuri,

you have got a nice ppt. You mentioned in the ppt various designs regarding needle free devices my thought is why do we need so many different types of designs , cant we have a single design like an injection as all the injectables woul be in the liquid form only.As you mentioned that there would be a dramatic change when any pharmaceutical company leads this product then why this so useful product has not yet been taken to market , are there any draw backs regarding manufacture or usage .Can u mention regarding its disadvantages if any.????
Can u also mention the materials of which these devices are made.

Shilpa.sambana
St ann's college of pharmacy
Vizianagaram
Andhra pradesh, India

shilpa.sambana st Ann's college of pharmacy
madhuri's picture

madhuri

Sun, 02/15/2009 - 07:24

thank u.good quetion. different models of needle free injections are used in order to deliver drugs of different forms(liquid,solid) and different molocular weights based on their efficiency of penetration through skin into the blood stream. drug penetration depends on the preesure applied.so different designs were designed for injecting different drugs. this needle free technology has developed to a great extent in all most all country's and it is in rapid ise in some fields only because of less awareness among the people. so we should provide a clear cut idea about this needle free techonology. another reason for less development of this needle free technologiy is its cost. due to its cost most of the people are neglecting the use of this needle free injections.so to increase its production into the market we should bring awareness among the people.it has no such a serious disadvantages except the following. 1.in case of liquid drugs when injected, the drug is not completely reaching the blood stream. 2. while injecting monoclonal antibodies less pressure should be applied because they are very sensitive.these needle free injections were made up of glass, plastic etc... i think now u have cleared ur doubts. thanks for commenting.if u have any doubts pls send comment.

madhuri
haritha8vvn's picture

haritha8vvn

Sun, 02/15/2009 - 13:36

hi madhur, ur ppt's topic is unique and i appreciate ur work, but everything has advantages and disadvantages. Can u please tell me what are the major/minor disadvantages in needle free injections? and what researches are conducted to overcome them?

V V N Haritha

MPharm-Pharmaceutics

madhuri's picture

madhuri

Mon, 03/09/2009 - 13:45

the main disadvantage of this technology is that its cost. other than this it has another disadvantage that when we r giving liquid medication by these devices is getting wasted i.e., the liquid medication is not completely entering into the blood circulation.so, it is getting wasted. research work has been going on to overcome this problem. thanks for ur comment.

madhuri
carizma_sha's picture

carizma_sha

Mon, 02/16/2009 - 05:20

Dear Madhuri,
a)I would like to know whether the devices that you mentioned as needle free technology are disposable or reusable or can be both ddepending on use?
b)Are there any devices still being developed for the purpose of mass vaccination that could help overcome the challenges of disease transmission through re-use of needles which frequently occurs in developing countries like india?
c)Needle free technology is widely used in western countries, but taking the pesent scenario into account, what steps are being taken for development of needle-free technology in india?
d)What are the other pitfalls related with the use of needles other than psychological resistance and needle phobia?

vedikag's picture

vedikag

Mon, 02/16/2009 - 14:32

The entire concept is really fascinating! I really liked the way you presented the topic, but what about the economical aspects associated besides the entire concept! As in what about its cost and relative price as compared to other common injections!
Vedika Gulati
Team Infinity
"∞"

Vedika Gulati Team Infinity "∞" http://www.pharmainfo.net/blog/team-infinity

madhuri's picture

madhuri

Mon, 02/23/2009 - 14:52

yes the cost of needle free injections is very high when compared with that of needle injections because of the equipment used in needle free injections is very expensive. so its cost will be high.thank for ur comment.keep it up.

madhuri
vedikag's picture

vedikag

Mon, 02/16/2009 - 14:33

The entire concept is really fascinating! I really liked the way you presented the topic, but what about the economical aspects associated besides the entire concept! As in what about its cost and relative price as compared to other common injections!
Vedika Gulati
Team Infinity
"∞"

Vedika Gulati Team Infinity "∞" http://www.pharmainfo.net/blog/team-infinity

madhuri's picture

madhuri

Thu, 02/19/2009 - 12:29

thank u for comment. the only economic aspect related to needle free technology is that its cost and no awareness among the people. its cost is very high when compared with that of normal injections. its cost is based on the type of material with which it is made up, the type of drug used i.e., for insulin injections the cost may range from 600/- and for harmone injections the cost is very high.ok u have cleared ur doubts? if u have any doubts send me.thank u

madhuri
zarrinfaria's picture

zarrinfaria

Tue, 02/17/2009 - 14:51

Thank you for providing the information on a new type of drug delivery sysytem....
Is this technology available in India???
If available which are the companies producing drugs based on this technology????
Good day..:))

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madhuri's picture

madhuri

Mon, 03/09/2009 - 13:49

yes it is available in india. needle free injections were manufactured by CIPLA pharmacy conpany in mumbai. thanks for sending comment.

madhuri
Himanshu saurabh's picture

Himanshu saurabh

Tue, 02/17/2009 - 16:06

Good presentation....
As this is a newly developed and highly sophisticated technology...the cost must be high...
Can you tell me the cost deifference between the drug therapy using needle free technology and normal conventional technology???

madhuri's picture

madhuri

Wed, 02/18/2009 - 18:37

thanks for comment
this technology is not so latest and it has been developed since 1960's but it is not implimented widely. their cost depends on diferent aspects like the type of drug used, type of injection used i.e.,. the technology used and the material with which it is made up.for example, the insulin needle free injections are most cheaper than others. they may range from Rs.600/-. the growth harmones injections are of high cost.

madhuri
majumdarshiv's picture

majumdarshiv

Wed, 02/18/2009 - 09:36

My Page : http://www.pharmainfo.net/majumdarshiv

Dear Madhuri,

I like the concept, but as usual the cost difference will make such technology rare in developing countries like india.

My query is that Needle free generally applicable to superficial or intermediate layer, will it be specifically given for special routes like intraartherial, or in between joints.

Best of luck

Shiv

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madhuri's picture

madhuri

Wed, 02/18/2009 - 18:28

thanks for ur comment
i agree with you that in countries like india it is very difficult to develop this type of technilogies because of high cost and the other reason is that improper awareness among the people.so, we should reduce the economic crisis and we should behave as main source for bringing awareness among the people. the companies which are involved in the production of these needle free injections should reduce their cost as much as possible.
these needle free injections are applicable to subcutaneous,intramuscular ....... routes but it is not apllicable b/w joints and intraartherial route.

madhuri
juhis's picture

juhis

Thu, 02/19/2009 - 12:39

great technology!
needle free injections have drug deleivery at which rate?is it too fast or too slow?
Juhi Sharma
Team Infinity
"∞"

Juhi Sharma http://www.pharmainfo.net/juhis/biography Team Infinity "∞" http://www.pharmainfo.net/blog/team-infinity

madhuri's picture

madhuri

Mon, 02/23/2009 - 14:33

nice question. the rate of drug entry into circulation depends on the pressure applied. it also depends on thickness of the skin. thanks for ur comment. all the best

madhuri
Kaushalpathak's picture

Kaushalpathak

Thu, 02/19/2009 - 13:08

I really appreciate your topic and the way you have presented it.
What about the frequency of administration, like say for example you mentioned about insulin administration through this delivery system so, how often you can administer the drug htru same site or we need to change the site of administration each time???
Also, in above case what is the advantage of this delivery system over insulin pens???
Thank you.

sirisha's picture

sirisha

Thu, 02/19/2009 - 17:00

Dear Madhuri....
Very good news for not only infants dear,,but also to others who are very much scared about syringes....
A quick question:
How the medication enters the circulation? Does the force applied through the tiny orifice itself will create an opening on the skin??
and can the same quantity be used as that of the syringes ??

Team: THE COGNITIVE MOLECULES

Sirisha Pingali

http://www.pharmainfo.net/sirisha

madhuri's picture

madhuri

Mon, 02/23/2009 - 14:29

nice question. yes the tiny orifice will create a hole i.e., it makes the skin pore more wide and allows the drug to enter the circulation.thanks for comment.all the best.

madhuri
gangadhar hari's picture

gangadhar hari

Thu, 02/19/2009 - 17:54

Nice topic.

Can u tell me how solid dosage forms can be administered through this? Don't they get squeezed in the tube? Do they require any extra pressure for their release?

Regards,

""PHARMA TROJANS""
http://www.pharmainfo.net/gangadhar-hari

Regards, http://www.pharmainfo.net/gangadhar-hari
gangadhar hari's picture

gangadhar hari

Thu, 02/19/2009 - 17:56

Nice topic.

Can u tell me how solid dosage forms can be administered through this? Don't they get squeezed in the tube? Do they require any extra pressure for their release?

Regards,

""PHARMA TROJANS""
http://www.pharmainfo.net/gangadhar-hari

Regards, http://www.pharmainfo.net/gangadhar-hari
kishore.reddy's picture

kishore.reddy

Fri, 02/20/2009 - 04:51

Nice work..
which is the best way for giving a drug in terms of efficiency???

madhuri's picture

madhuri

Mon, 02/23/2009 - 14:24

the efficiency depends onthe pressure applied. but if the injection is made up of glass it is difficult to apply more pressure because of the reason that the glass breaks when we apply more pressure on piston. if the injection is made up of plastic we can apply the required pressure. thank u for comment. all the best.

madhuri
Jasmine Jose's picture

Jasmine Jose

Fri, 02/20/2009 - 13:49

Dear Madhuri!
Ur ppt is very interestin!
Does the extent of entry of the drug into the circulation hav to do anything with the quantity of fat deposited beneath the skin?
Team -The Cognitive Molecules!

santosh kumar. JH's picture

santosh kumar. JH

Fri, 02/20/2009 - 15:18

How about using the silicon needles in this technology?

Regards,

"PHARMERS"
http://www.pharmainfo.net/santosh-kumar-jh

Regards, Santosh Kumar http://www.pharmainfo.net/santosh-kumar-jh
ks kumar upadhyayula's picture

ks kumar upadhyayula

Fri, 02/20/2009 - 17:49

Good presentation Ms.Madhuri.It would be nice if you can better elucidate the information regarding professional grade injection systems mentioned.
Regards,

"PHARMERS"
http://www.pharmainfo.net/ks-kumar-upadhyayula

http://www.pharmainfo.net/ks-kumar-upadhyayula

madhuri's picture

madhuri

Thu, 04/09/2009 - 14:11

thanks for your suggestion. i will do better.

madhuri
ayushsinghal's picture

ayushsinghal

Sat, 02/21/2009 - 14:53

good work...
suppose in if we have an option of I.V. route only? can we modify this technology to make iv route accesses able?

Ayush A. Singhal RPCP, CHANGA GUJARAT http://www.pharmainfo.net/ayushsinghal/biography
raghanaveen's picture

raghanaveen

Sun, 02/22/2009 - 14:38

Your presentation is good .can you tell me about the following points:
a)Do you think that it is possible to replace the present injection with needle fee injection tecnology and is it affodable to do that?
b)You said that this way of injection causes minimal skin response and with low sensation ,and you said that medication is forced with high speed through a orifice which creates high pressure .So by these points I want to know how the patient would feel less sensation even there is forced high pressured fluid flow through the skin?
c)Can you give me the information about that ay what pressure the fluid is injected?
Ragha Naveen

Ragha Naveen

e-reporter, RCP
afsanehr's picture

afsanehr

Fri, 02/27/2009 - 22:26

Nice presentation.................
Can you tell me why this is not widely accepted in our country?
What are the barriers for this

PHARMACY CARES

AFSANEH REZVAN
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The Pharmacy Cares
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madhuri's picture

madhuri

Thu, 04/09/2009 - 14:04

The main reason for its underdevelopment is its cost and when liquid dosage form is given, the complete dosage form is not reching the blood circulation.some amount of drug is getting waseted.so, it is not prefered widely. thaks for ur comment.

madhuri
devyani's picture

devyani

Fri, 02/27/2009 - 23:01

Good presentation!!!

My question is can this technique prevent lipodystrophy (local) side effect in insulin users?

PHARMACY CARES

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