Nutrigenomics- Developing Personalised Diets for Disease Prevention

Nutrigenomics focuses on the effect of nutrients on the genome, proteome, and metabolome. It is applying the sciences of genomics, transcriptomics, proteomics and metabolomics to human nutrition in order to understand the relationship between nutrition and health. In order to address the increasing incidence of these diet-related-diseases, the role of diet and nutrition has been and continues to be extensively studied. Nutrigenomics has been defined as the application of high-throughput genomic tools in nutrition research. The term high throughput tools in nutrigenomics refers to genetic tools that enable literally millions of genetic screening tests to be conducted at a single time. When such high throughput screening is applied in nutrition research, it allows the examination of how nutrients affect the thousands of genes present in the human genome.

Nutrigenomics involves the characterization of gene products and the physiological function and interactions of these products. This includes how nutrients impact on the production and action of specific gene products and how these proteins in turn affect the response to nutrients. In future, nutrigenomics may potentially help guide the development of customized diets based on an individual’s genetic make-up. Genetic disorders which cause pathological effects were described.

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eswar's picture

Dear Aparna,
Ur ppt is interesting!
Do U mean that Nutrigenomics is a remedy for genetic disorders?
Are there any practical examples?

Regards
eswar :-)

Regards

ESWAR :-)

aparna's picture

According to researchers exploring the field of nutrigenomics personalized dietary interventions can be designed to prevent or modify future disease susceptibility.

Personalised diets would include modifying either diet or the biochemical response to food exposure to prevent disease in individuals shown to be susceptible to the consequences of unfavourable dietary/genomic interactions.

The researchers said that nutrigenomics might potentially help guide the development of customized diets based on an individual''s genetic make-up.

Practical Examples:

A handful of companies is already offering genomics profiles and nutritional supplements to early adopters. One company in America already offers a genetics testing service. Clients pay up to $1,500 (£933) for a preventive health profile.

The NCMHD Center of Excellence for NUTRITIONAL GENOMICS is working in this direction still... many other organisations are also working on it...

The Center is using a multidisciplinary approach to investigate the influence of diet and individual genetic variation as risk factors for health disparities in racial/ethnic populations in the U.S.

eswar's picture

Dear Aparna,
Thanks for clearing the queries.
I think there is National Nutrition Centre in Hyderabad!
What abt its research?
Did U got any info abt that in your findings?
Regards
eswar :-)

Regards

ESWAR :-)

aparna's picture

to my knowledge national nutrition centre in hyderabad is not working on this at present...

haritha8vvn's picture

Hi Aparna, Ur ppt is interesting, but can u please help me in informing my question:- keeping in view of recent scenario can you tell me if there are any researches going on presently in the field of Nutrigenomics not including the future aspects?

V V N Haritha

MPharm-Pharmaceutics

aparna's picture

hello..
at present many organisations n scientists r xploring the field of nutrigenomics....
der z lot to xplore still........n contribute..

carizma_sha's picture

Aparna , you have chosen a refreshingly different topic for yor presentation.....please do spare some time to answer these questons:-Is it(nutrigenomics) an area of ongoing research?..i wish to know your views on its practical applicability...How is the consumer supposed to get his/her genetic profile prepared?Besides i wonder whether the diets prescribed for the consumer are easy to implement into daily routine? What is the guarentee that the diets will work?
-How far does the statement " our emotions and thoughts can trigger the gene on/off" hold true?What role,if any do emotions play in preventing or curing illness? Barring a few stories of miraculous recoveries, CAN we actually alter the course of disease by manipulating psychlogical factors? Does the study of effect of emotions in disease come under nutrigenomics or neuropsychiatry?
-what does the term "dietary signature" imply?

aparna's picture

yes it’s an ongoing research…
there are some organizations in US who can help ppl in getting der personalized diets..
the diets prescribed are absolutely easy to implement…….because they just modify our daily diet…
we cannot give 100% assurance to any medicine I suppose…..it differs frm person to person….

Our emotions have gr8 impact on our diseases….emotional well being is always imp…unless we r psychologically strong..no disease can be treated…..by any specialist I suppose……
Study of emotions is a part of nutrigenomic study….as I told it had lot of disciplines involved in it……..

Dietary signature is the particular effect it generates in an individual

majumdarshiv's picture

My Page : http://www.pharmainfo.net/majumdarshiv

Dear Aparna,

Your survey on Nutrigenomics, is really appreciable. I have some query related to its impact on global level,

1) Is there any policy is made by or in plan under consideration of WHO?
2) In underdeveloped & Developing countries, where we have very limited finance to spend on major diseases & life saving drugs, do you think it will survive in such conditions.
3) Is it started in India?

Overall presentation was good, keep sending such informative things.

Best of Luck.

Regards
Shiv
Team INFINITY

aparna's picture

Thank u so much sir…
1) As this is an ongoing research field no policy has been made yet in WHO….
2) As this doesn’t involve much xpenditure it will be of gr8 help in underdeveloped n developing countries……simple modification in our diet easy extremely reliable source of treatment in a country like ours…
3) This is nt started in India yet…..

zarrinfaria's picture

A very good effort....great source of information...In one of your slides you have mentioned "Nutrigenomics- disciplines" In which you have mentioned various fields contributing to nutrigenomics.
Can you please tell me if a pharmacist- specailised in medicinal chemistry or pharmaceutics can also contribute to the field and in what way??
Have a good day...:))

aparna's picture

Thank u so much Zarrin..
The branch of medicinal chemistry and pharmaceutics can also contribute a lil to the research in this field but am not sure of much requirement form dis field....

these branches can help in knowing about the drugs used for the disease previously..and the individual's response ti tht....based on the drug we can carefully design the diet too...

harrybasson's picture

Very good concept madam,
But is it possible to treat disease by giving micro nutrients and r these r available in market

aparna's picture

Thank u so much sir...
A new Nutrigenomic supplement category has been created for the NUTRILITE brand. All supplements in this category will be designed for certain genotypes

Himanshu saurabh's picture

Good presentation...
Can you provide me with the information on which country or the research institute that has contributed most on the subject of Nutrigenomics??

aparna's picture

Thank u so much...
The NCMHD Center of Excellence for NUTRITIONAL GENOMICS which is under University of california is contributing to great extent...

vedikag's picture

ur work is really appreciable !
its really nice n simple concept !
can it b used to cure congenital disease ?
how can one go through a process of nutrigenomics ?

Vedika Gulati
Team Infinity
"∞"

Vedika Gulati Team Infinity "∞" http://www.pharmainfo.net/blog/team-infinity

aparna's picture

Thank u so much...
Acc to the researh congenital diseases cannot be cured completely but....the severity n suffering can reduced to the max xtent by this method...n we can make sure tht the individual leads a normal life...

Going through Process of nutrigenomics is easy...

A trip to the diet doc, circa 2013. You prick your finger, draw a little blood and send it, with $100, to a consumer genomics lab in California. There, it's passed through a mass spectrometer for protein analysis and cross-referenced to your DNA profile. A few days later, you get an email message with your recommended diet for the next four weeks. It doesn't look too bad: lots of salmon, spinach, selenium supplements, bread with olive oil.

Your diet is uniquely tailored. It is determined by the specific demands of your genetic signature and perfectly balances your micro- and macro-nutrient needs....

Abhamajumdar's picture

hello Aparna,
I am quite interested in knowing more about the impact of emotions on health

aparna's picture

thank u so much...
effect of emotions is the most imp part of any treatment...As we know based on emotional factor also the dose of drug changes....
this shows the importance of emotions on our health.....50% of the treatment depends on th emotional well being........

juhis's picture

great presentation.
explained really very well.
is nutrigenomics practice followed in india ?
what scope it has in near future with the devolopment of biotech.?
Juhi Sharma
Team Infinity
"∞"

aparna's picture

Thank u so much...
Nutrigenomics is yet to be followed in our country...
Though we r inclined to biotechnology much these days...nutrigenomics is sure to draw the attention because of its simplicity.....easy to follow........n it is highly economical too.........

Kaushalpathak's picture

very interesting topic. No doubt, if this field well explored will certainly improve the patient care prophylactically.What is the current scenario of nutrigenomics in India and Abroad??? How far it is a success???

aparna's picture

Thank u so much...
In India much attention is not being given to nutrigenomics…
But in most of the developed countries(T be specific US) scientists are doing their best to xplore dis field……

They are successful to gr8 extent…they could launch many nutritional supplements into market now….. Prestigious brands have taken up the job to introduce these supplements into market….

sirisha's picture

Dear Aparna....
Very common topic n at the same time many of them dont know the theory behind this.....
Does the sensor system that detects nutrients work normally everytime??

aparna's picture

The sensor system cannot detect the nutrients normally all the time…. It will not function properly during diseased condition which is the base of nutrigenomic study

gangadhar hari's picture

Excellent work

Does this method afford in curing genetically inherited nuritional disorders?

Regards,

""PHARMA TROJANS""
http://www.pharmainfo.net/gangadhar-hari

aparna's picture

Thank u so much sir...
genetically inherited nutritional disorders cannot be cured completely..but we can reduce the severity and its effect on the system...
we can jus prevent their ocurence.......

kishore.reddy's picture

Its very interesting.
Is there any research going on Nutrigenomics in India???

aparna's picture

Thank u so much...
During my work...i did not find any institution working on nutrigenomis from India....but its suppliments hav been sent to india....

Khushbu Hasmukh Patel's picture

how nutrients impact on the production and action of specific gene products ?
panacea group

K.H.Patel.
My profile link is
http://www.pharmainfo.net/khushbu-hasmukh-patel

aparna's picture

nutrients help to triggger the defective gene based on their vibrational frequeny..n response....

Jasmine Jose's picture

Hie Aparna!
Ur ppt is quite novel and informative!
How effective is Nutrigenomics in curing various complex diseases?
THE COGNITIVE MOLECULES

aparna's picture

It is simple n easy for the patient to follow..so it wouldnt effect the patient's life much and der will be no side effects n unnatural actions also...as can be observed while using drugs

santosh kumar. JH's picture

Good way done and what about the Brain fog?Please provide information
Regards,

"PHARMERS"
http://www.pharmainfo.net/santosh-kumar-jh

aparna's picture

As Brain fog may be due to several factors it can be treated in many ways......the term used for sleep inertia can be treated by nutrigenomics in some cases if it was due to nutritional imbalance....
if it is caused by some other factors we are not sure of complete treatment..

regards
APARNA SANNAPu

aparna's picture

to my knowledge national nutrition centre in hyderabad is not working on this at present...

ks kumar upadhyayula's picture

Ms.Aparna,Good and your approach to the presentation is really awesome.It will be nice if you can tell how to activate the regenerative DNA through supercharging?
Regards,

"PHARMERS"
http://www.pharmainfo.net/ks-kumar-upadhyayula

aparna's picture

Thnk u so much sir...
As i mentioned in my presentation the vibrational frequency brought about by the food we take...will help to activate the regenerative DNA....

Supercharging is completely based on the concept of vibrational frequency.

aparna's picture

hello..
at present many organisations n scientists r xploring the field of nutrigenomics....
der z lot to xplore still........n contribute...

aparna's picture

Thnk u so much sir...
As i mentioned in my presentation the vibrational frequency brought about by the food we take...will help to activate the regenerative DNA....

Supercharging is completely based on the concept of vibrational frequency..

aparna's picture

thnk u so much....
yes it’s an ongoing research…
there are some organizations in US who can help ppl in getting der personalized diets..
the diets prescribed are absolutely easy to implement…….because they just modify our daily diet…
we cannot give 100% assurance to any medicine I suppose…..it differs frm person to person….

Our emotions have gr8 impact on our diseases….emotional well being is always imp…unless we r psychologically strong..no disease can be treated…..by any specialist I suppose……
Study of emotions is a part of nutrigenomic study….as I told it had lot of disciplines involved in it……..

Dietary signature is the particular effect it generates in an individual…

udayasree datla's picture

The presentation is very eye-catching and marvellous.How can the nutrient based diet effect the genetic make-up of each individual in a different way ?
Regards,
"PHARMERS"
http://www.pharmainfo.net/udayasree-datla

aparna's picture

Thank u so much udayasree..

As we know already individual response to any drug varies form person to person..........its the same here..........each individual responds differently to the same diet.........

this differene in response is attributed to the individual's genetic makeup....
based on this fact we can alter the defective gene's response......by altering our diet.....

aparna's picture

Thank u so much udayasree..

As we know already individual response to any drug varies form person to person..........its the same here..........each individual responds differently to the same diet.........

this differene in response is attributed to the individual's genetic makeup....
based on this fact we can alter the defective gene's response......by altering our diet.....

aparna's picture

Thank u so much sir…
1) As this is an ongoing research field no policy has been made yet in WHO….
2) As this doesn’t involve much xpenditure it will be of gr8 help in underdeveloped n developing countries……simple modification in our diet easy extremely reliable source of treatment in a country like ours…
3) This is nt started in India yet…..

aparna's picture

Thank u so much Zarrin..
The branch of medicinal chemistry and pharmaceutics can also contribute a lil to the research in this field but am not sure of much requirement form dis field....

these branches can help in knowing about the drugs used for the disease previously..and the individual's response ti tht....based on the drug we can carefully design the diet too....

aparna's picture

Thank u so much sir...
A new Nutrigenomic supplement category has been created for the NUTRILITE brand. All supplements in this category will be designed for certain genotypes.

aparna's picture

Thank u so much...
The NCMHD Center of Excellence for NUTRITIONAL GENOMICS which is under University of california is contributing to great extent....

aparna's picture

Thank u so much...
Acc to the researh congenital diseases cannot be cured completely but....the severity n suffering can reduced to the max xtent by this method...n we can make sure tht the individual leads a normal life...

Going through Process of nutrigenomics is easy...

A trip to the diet doc, circa 2013. You prick your finger, draw a little blood and send it, with $100, to a consumer genomics lab in California. There, it's passed through a mass spectrometer for protein analysis and cross-referenced to your DNA profile. A few days later, you get an email message with your recommended diet for the next four weeks. It doesn't look too bad: lots of salmon, spinach, selenium supplements, bread with olive oil.

Your diet is uniquely tailored. It is determined by the specific demands of your genetic signature and perfectly balances your micro- and macro-nutrient needs....

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