Pharmaceuticals for Astronauts in Space

yes naman this section of pharmacy is really catchy and interesting....

yes!!!! since when drugs actions take place keeping our earth factors in the role. but if we use these drugs at zero gravity level whare astronauts have to worked there it somewhat litle different. . We discover drug molecule keeping our environmental factors as conditions and effects of atmosphere on our health first thing you know that there is a space work station in the space where sunita williams worked there. In space there is no gravity .gravity matters a lot in case of peristaltic movement of bolus inside the oesophegus. gravity also matters in blood flow.In space astronauts swallows their food forcefully through pipes. NSBRI(national space biomedical research institute.a section of NASA) projects address space health concerns such as bone and muscle loss, cardiovascular changes, balance and orientation problems, neurobehavioral and psychosocial factors, radiation exposure, remote medical care and research capabilities, and neurobehavioral and psychosocial factors, and habitability and performance issues such as sleep cycles and lunar dust exposure.these problems that generally happens while astronauts reach in space. NSBRI works to overcome these problems by preparing formulations that supports at zero gravity zone Research findings will also impact the understanding and treatment of similar medical conditions experienced on Earth.
Following long missions, returning astronauts may experience reduced exercise and performance capacity, and a drop in blood pressure causing faintness upon standing. These conditions limit an astronaut’s ability to function following landing. If an emergency situation occurred, these limits could impact the crew’s ability to exit the spacecraft. On long-duration missions, deconditioning will lead to reduced cardiac mass. for that thing we use diff. DDS.
In space blood pressure get increases and joint cavity starts paining. For that ailment we need drugs which works. Some drugs gives different results in space. for example NABA n-acetyl butyric acid when act on liver it gives an emperical results for glycolysis . but if we administered at space it creates toxicity.The whole information is kept confidential inNASA sometimes.

insilco models are those models which are computational models of ADME charts that is extractd by various long process.
it is done through different softwares . as i've mentioned in my slide that the mps software gives the detail ADME data within a very short period of time and with very less efforts.
thanks

hello sir
It is very much interesting and catchy..

Space medicines are concerned about the medicines that are used by astronauts while working in space to remain healthy and active. A section of NASA NSBRI ( national space biomedical research institute) works on this .NSBRI research seeks solutions to health concerns facing astronauts on long missions. Patients on Earth suffering from similar conditions will benefit from these advances.NSBRI discoveries impact medical care on Earth. While solving space health issues, the Institute is transferring the solutions to patients suffering from similar conditions, including osteoporosis, muscle wasting, shift-related sleep disorders, balance disorders and cardiovascular system problems.Reduced exercise and performance capacity, and a drop in blood pressure causing faintness upon standing. These conditions limit an astronaut’s ability to function following landing. If an emergency situation occurred, these limits could impact the crew’s ability to exit the spacecraft. On long-duration missions, deconditioning will lead to reduced cardiac mass.In space blood pressure get increases and joint cavity starts paining. For that ailment we need drugs which works. Some drugs gives different results in space. for example NABA n-acetyl butyric acid when act on liver it gives an emperical results for glycolysis . but if we administered at space it creates toxicity.
Scientists working on NSBRI create that drug dosage forms and they test it on zero gravity.( tests on rat.mices on high altitude flying jet aircraft where there is less gravity).
The forum NSBRI has all the rights and patent by USFDA for manufacturing thse drugs.Because it is a gov. related work. and its use is also limited that is why NASA is not giving the rights to other mfg. companies...

thanks
eagerly waiting for your comments...
.

In space there is no gravity .gravity matters a lot in case of peristaltic movement of bolus inside the oesophegus. gravity also matters in blood flow.In space astronauts swallows their food forcefully through pipes. NSBRI(national space biomedical research institute.a section of NASA) projects address space health concerns such as bone and muscle loss, cardiovascular changes, balance and orientation problems, neurobehavioral and psychosocial factors, radiation exposure, remote medical care and research capabilities, and neurobehavioral and psychosocial factors, and habitability and performance issues such as sleep cycles and lunar dust exposure.these problems that generally happens while astronauts reach in space. NSBRI works to overcome these problems by preparing formulations that supports at zero gravity zone Research findings will also impact the understanding and treatment of similar medical conditions experienced on Earth.
Following long missions, returning astronauts may experience reduced exercise and performance capacity, and a drop in blood pressure causing faintness upon standing. These conditions limit an astronaut’s ability to function following landing. If an emergency situation occurred, these limits could impact the crew’s ability to exit the spacecraft. On long-duration missions, deconditioning will lead to reduced cardiac mass. for that thing we use diff. DDS.
In space blood pressure get increases and joint cavity starts paining. For that ailment we need drugs which works. Some drugs gives different results in space. for example NABA n-acetyl butyric acid when act on liver it gives an emperical results for glycolysis . but if we administered at space it creates toxicity.The whole information is kept confidential inNASA sometimes

FOR FURTHER QUERIES YOU CAN POST COMMENT . I' M EAGERLY WAITING FOR YOUR RESPONSE

yes!!!! since when drugs actions takes place keeping our earth factors in the role. but if we use these drugs at zreo gravity level whare astronauts has to worked there it somewhat litle different. . We discover drug molecule keeping our environmental factors as conditions and effects of atmosphere on our health first thing you know that there is a space work station in the space where sunita williams worked there. In space there is no gravity .gravity matters a lot in case of peristaltic movement of bolus inside the oesophegus. gravity also matters in blood flow.In space astronauts swallows their food forcefully through pipes. NSBRI(national space biomedical research institute.a section of NASA) projects address space health concerns such as bone and muscle loss, cardiovascular changes, balance and orientation problems, neurobehavioral and psychosocial factors, radiation exposure, remote medical care and research capabilities, and neurobehavioral and psychosocial factors, and habitability and performance issues such as sleep cycles and lunar dust exposure.these problems that generally happens while astronauts reach in space. NSBRI works to overcome these problems by preparing formulations that supports at zero gravity zone Research findings will also impact the understanding and treatment of similar medical conditions experienced on Earth.
Following long missions, returning astronauts may experience reduced exercise and performance capacity, and a drop in blood pressure causing faintness upon standing. These conditions limit an astronaut’s ability to function following landing. If an emergency situation occurred, these limits could impact the crew’s ability to exit the spacecraft. On long-duration missions, deconditioning will lead to reduced cardiac mass. for that thing we use diff. DDS.
In space blood pressure get increases and joint cavity starts paining. For that ailment we need drugs which works. Some drugs gives different results in space. for example NABA n-acetyl butyric acid when act on liver it gives an emperical results for glycolysis . but if we administered at space it creates toxicity.The whole information is kept confidential inNASA sometimes

FOR FURTHER QUERIES YOU CAN POST COMMENT . I' M EAGERLY WAITING FOR YOUR RESPONSE

yes!!!! since when drugs actions take place keeping our earth factors in the role. but if we use these drugs at zero gravity level whare astronauts have to worked there it somewhat litle different. . We discover drug molecule keeping our environmental factors as conditions and effects of atmosphere on our health first thing you know that there is a space work station in the space where sunita williams worked there. In space there is no gravity .gravity matters a lot in case of peristaltic movement of bolus inside the oesophegus. gravity also matters in blood flow.In space astronauts swallows their food forcefully through pipes. NSBRI(national space biomedical research institute.a section of NASA) projects address space health concerns such as bone and muscle loss, cardiovascular changes, balance and orientation problems, neurobehavioral and psychosocial factors, radiation exposure, remote medical care and research capabilities, and neurobehavioral and psychosocial factors, and habitability and performance issues such as sleep cycles and lunar dust exposure.these problems that generally happens while astronauts reach in space. NSBRI works to overcome these problems by preparing formulations that supports at zero gravity zone Research findings will also impact the understanding and treatment of similar medical conditions experienced on Earth.
Following long missions, returning astronauts may experience reduced exercise and performance capacity, and a drop in blood pressure causing faintness upon standing. These conditions limit an astronaut’s ability to function following landing. If an emergency situation occurred, these limits could impact the crew’s ability to exit the spacecraft. On long-duration missions, deconditioning will lead to reduced cardiac mass. for that thing we use diff. DDS.
In space blood pressure get increases and joint cavity starts paining. For that ailment we need drugs which works. Some drugs gives different results in space. for example NABA n-acetyl butyric acid when act on liver it gives an emperical results for glycolysis . but if we administered at space it creates toxicity.The whole information is kept confidential inNASA sometimes

FOR FURTHER QUERIES YOU CAN POST COMMENT . I' M EAGERLY WAITING FOR YOUR RESPONSE

thanks for your comments
since when drugs actions take place keeping our earth factors in the role. but if we use these drugs at zero gravity level whare astronauts have to worked there it somewhat litle different. . We discover drug molecule keeping our environmental factors as conditions and effects of atmosphere on our health first thing you know that there is a space work station in the space where sunita williams worked there. In space there is no gravity .gravity matters a lot in case of peristaltic movement of bolus inside the oesophegus. gravity also matters in blood flow.In space astronauts swallows their food forcefully through pipes. NSBRI(national space biomedical research institute.a section of NASA) projects address space health concerns such as bone and muscle loss, cardiovascular changes, balance and orientation problems, neurobehavioral and psychosocial factors, radiation exposure, remote medical care and research capabilities, and neurobehavioral and psychosocial factors, and habitability and performance issues such as sleep cycles and lunar dust exposure.these problems that generally happens while astronauts reach in space. NSBRI works to overcome these problems by preparing formulations that supports at zero gravity zone Research findings will also impact the understanding and treatment of similar medical conditions experienced on Earth.
Following long missions, returning astronauts may experience reduced exercise and performance capacity, and a drop in blood pressure causing faintness upon standing. These conditions limit an astronaut’s ability to function following landing. If an emergency situation occurred, these limits could impact the crew’s ability to exit the spacecraft. On long-duration missions, deconditioning will lead to reduced cardiac mass. for that thing we use diff. DDS.
In space blood pressure get increases and joint cavity starts paining. For that ailment we need drugs which works. Some drugs gives different results in space. for example NABA n-acetyl butyric acid when act on liver it gives an emperical results for glycolysis . but if we administered at space it creates toxicity.The whole information is kept confidential inNASA sometimes

FOR FURTHER QUERIES YOU CAN POST COMMENT . I' M EAGERLY WAITING FOR YOUR RESPONSE

some of the drugs show same results not all of the other drugs.
for example NABA n-acetyl butyric acid when act on liver it gives an emperical results for glycolysis . but if we administered at space it creates toxicity.

thanks for your question.

That's really a nice explanation Pulkit.
All the very best

Regards,

""PHARMA TROJANS""
http://www.pharmainfo.net/gangadhar-hari

yes!!!! since when drugs actions take place keeping our earth factors in the role. but if we use these drugs at zreo gravity level whare astronauts have to work there it somewhat litle different. . We discover drug molecule keeping our environmental factors as conditions and effects of atmosphere on our health first thing you know that there is a space work station in the space where sunita williams worked there. In space there is no gravity .gravity matters a lot in case of peristaltic movement of bolus inside the oesophegus. gravity also matters in blood flow.In space astronauts swallows their food forcefully through pipes. NSBRI(national space biomedical research institute.a section of NASA) projects address space health concerns such as bone and muscle loss, cardiovascular changes, balance and orientation problems, neurobehavioral and psychosocial factors, radiation exposure, remote medical care and research capabilities, and neurobehavioral and psychosocial factors, and habitability and performance issues such as sleep cycles and lunar dust exposure.these problems that generally happens while astronauts reach in space. NSBRI works to overcome these problems by preparing formulations that supports at zero gravity zone Research findings will also impact the understanding and treatment of similar medical conditions experienced on Earth.
Following long missions, returning astronauts may experience reduced exercise and performance capacity, and a drop in blood pressure causing faintness upon standing. These conditions limit an astronaut’s ability to function following landing. If an emergency situation occurred, these limits could impact the crew’s ability to exit the spacecraft. On long-duration missions, deconditioning will lead to reduced cardiac mass. for that thing we use diff. DDS.
In space blood pressure get increases and joint cavity starts paining. For that ailment we need drugs which works. Some drugs gives different results in space. for example NABA n-acetyl butyric acid when act on liver it gives an emperical results for glycolysis . but if we administered at space it creates toxicity.The whole information is kept confidential inNASA sometimes

FOR FURTHER QUERIES YOU CAN POST COMMENT . I' M EAGERLY WAITING FOR YOUR RESPONSE

yes ma'm its a li'l bit difficult .In a simple ways if you had gone through my ppt presentation you will find that I have been let you know that the software mentioned in my slide gives the multi parametric values in just a lesser time where by using the other ways it takes long long paper work of these values(ADME DATA) having the risk of effectiveness. In simple sentence that R&D of such companies using thse insilico softwares for accurate multi parameteres more accurately and more compiled manner. Means computers softwares role in drug evalustion and desingning too.

I 'm eagerly waiting for your response.

thanks for appreciating my work.
but I'm waiting for your questions based on my work

thanks

thanks sir

as I described in my ppt slides while designing the drugs and evalution of certain drug factors such as its receptor target model, drug protein influence on the ADME in humans, blood brain barrier etc.A 3d structure of drug molecule in these insilico models some of these lead compounds were later successfully optimized by using the 3D structure of the target GPCR as a guideline. This work paves the way to a broader application of 3D models inGPCRdrug discovery, compensating for the limited number of x-ray structures available in this important field.
Factors for evaluating drugs:::

1. NCE GAP
2. BLOOD BRAIN BARREIR
3. bioequivalence studies
4. pharmacodynamic studies
5. clinical studies
6. in vitro studies

wiating for your response!!!

we discover drug molecule keeping our environmental factors as conditions and effects of atmosphere on our health first thing you know that there is a space work station in the space where sunita williams worked there. In space there is no gravity .gravity matters a lot in case of peristaltic movement of bolus inside the oesophegus. gravity also matters in blood flow.In space astronauts swallows their food forcefully through pipes. NSBRI(national space biomedical research institute.a section of NASA) projects address space health concerns such as bone and muscle loss, cardiovascular changes, balance and orientation problems, neurobehavioral and psychosocial factors, radiation exposure, remote medical care and research capabilities, and neurobehavioral and psychosocial factors, and habitability and performance issues such as sleep cycles and lunar dust exposure.these problems that generally happens while astronauts reach in space. NSBRI works to overcome these problems by preparing formulations that supports at zero gravity zone Research findings will also impact the understanding and treatment of similar medical conditions experienced on Earth.
Following long missions, returning astronauts may experience reduced exercise and performance capacity, and a drop in blood pressure causing faintness upon standing. These conditions limit an astronaut’s ability to function following landing. If an emergency situation occurred, these limits could impact the crew’s ability to exit the spacecraft. On long-duration missions, deconditioning will lead to reduced cardiac mass. for that thing we use diff. DDS.
In space blood pressure get increases and joint cavity starts paining. For that ailment we need drugs which works. Some drugs gives different results in space. for example NABA n-acetyl butyric acid when act on liver it gives an emperical results for glycolysis . but if we administered at space it creates toxicity.

FOR FURTHER QUERIES YOU CAN POST COMMENT . I' M EAGERLY WAITING FOR YOUR RESPONSE

it is truely possible. it has been recently discovered by the scientists working for Pfizer.

thanks for the suggestion. As I explained it as a flowchart and one example of software. first thing you know that there is a space work station in the space where sunita williams worked there. In space there is no gravity .gravity matters a lot in case of peristaltic movement of bolus inside the oesophegus. gravity also matters in blood flow.In space astronauts swallows their food forcefully through pipes. NSBRI projects address space health concerns such as bone and muscle loss, cardiovascular changes, balance and orientation problems, neurobehavioral and psychosocial factors, radiation exposure, remote medical care and research capabilities, and neurobehavioral and psychosocial factors, and habitability and performance issues such as sleep cycles and lunar dust exposure. Research findings will also impact the understanding and treatment of similar medical conditions experienced on Earth.
Following long missions, returning astronauts may experience reduced exercise and performance capacity, and a drop in blood pressure causing faintness upon standing. These conditions limit an astronaut’s ability to function following landing. If an emergency situation occurred, these limits could impact the crew’s ability to exit the spacecraft. On long-duration missions, deconditioning will lead to reduced cardiac mass. for that thing we use diff. DDS.
In space blood pressure get increases and joint cavity starts paining. For that ailment we need drugs which works. Some drugs gives different results in space. for example NABA n-acetyl butyric acid when act on liver it gives an emperical results for glycolysis . but if we administered at space it creates toxicity.

thanks for the suggesion...

yes a section of NASA that is NSBRI(national institute of space biomedical space and research institute) works on medicines for astronauts.
CAREER.Through teacher professional development programs, curriculum writing, classroom materials, community outreach and museum programs, summer research opportunities and internships, collegiate-level courses, electronic materials and informational pieces, the message of "Down-to-Earth" space research activities and discoveries are transferred to teachers, students and the public. NSBRI is supporting its fourth class of postdoctoral fellows and a Graduate Education Program in Space Life Sciences.some institutes are that works with NSBRI
Baylor College of Medicine (BCM)—From Outer Space to Inner Space: Sharing NSBRI Progress with the Community.
Massachusetts Institute of Technology (MIT)—Space Biomedical Sciences and Engineering Curriculum and Outreach Project.
Morehouse School of Medicine (MSM)—Secondary and College Education for the Next Generation of Space Life Scientists.
Mount Sinai School of Medicine (MSSM)—Defying Gravity: Enduring Life in Space.
The University of Washington (UW)—Northwest Outreach Program on Space Biomedicine Research.

First thing you know that there is a space work station in the space where sunita williams worked there. In space there is no gravity .gravity matters a lot in case of peristaltic movement of bolus inside the oesophegus. gravity also matters in blood flow.In space astronauts swallows their food forcefully through pipes. NSBRI projects address space health concerns such as bone and muscle loss, cardiovascular changes, balance and orientation problems, neurobehavioral and psychosocial factors, radiation exposure, remote medical care and research capabilities, and neurobehavioral and psychosocial factors, and habitability and performance issues such as sleep cycles and lunar dust exposure. Research findings will also impact the understanding and treatment of similar medical conditions experienced on Earth.
Following long missions, returning astronauts may experience reduced exercise and performance capacity, and a drop in blood pressure causing faintness upon standing. These conditions limit an astronaut’s ability to function following landing. If an emergency situation occurred, these limits could impact the crew’s ability to exit the spacecraft. On long-duration missions, deconditioning will lead to reduced cardiac mass. for that thing we use diff. DDS.
In space blood pressure get increases and joint cavity starts paining. For that ailment we need drugs which works. Some drugs gives different results in space. for example NABA n-acetyl butyric acid when act on liver it gives an emperical results for glycolysis . but if we administered at space it creates toxicity.

oh.. its true that pharm. is related to every creature and and after advancement in space field the astronauts also required some medicines so that they can work on the space for many weeks without any health loss.

A section of NASA NSBRI ( national space biomedical research institute) works on this .NSBRI research seeks solutions to health concerns facing astronauts on long missions. Patients on Earth suffering from similar conditions will benefit from these advances.NSBRI discoveries impact medical care on Earth. While solving space health issues, the Institute is transferring the solutions to patients suffering from similar conditions, including osteoporosis, muscle wasting, shift-related sleep disorders, balance disorders and cardiovascular system problems.I'm giving you the e-mail id of this institute

National Space Biomedical Research Institute
One Baylor Plaza, NA-425, Houston, TX 77030
713-798-7412 (phone), 713-798-7413 (fax)
For more information contact info@www.nsbri.org

you can search on google typing NSBRI THANKS for giving me 2 stars . but if you would give me more I'd better for my contest competetion.

no its not like that. if you've to know the PSA AND HBD of every drug , you 've to do much more effort and calculations. That is why this softwre created for easy and harmonic ADME data.You can get its great benifit and advantages out of it .Its a simple insilico software where we can find out many multi parameters with such little time. One ggreat advantage that it is applicable in most of the drug reacting factors.

Since you've given the important information concerning about the algorithm protocol for right and optimum formulation and calculated ways of dose in asthma via aerosols.
i appreciate for that. I know little knowledge about these aerosols. In my ppt presentation i'm putting the invention of the insilico on the basis of ADME HIT TRAIGE by generating the huge invitro and invivo data into systematic ADME data harmonically and to short or, no ADME DATA too. This is the technology from we can use in every drug delivery( includindg your asthamatic action) coz of its multi results in single software with much little time and detailed protocol rather of being its elusive. The outcome is that now SAR can be identified which could to stable templates.The ADME weak spot can be easily checked.
IN early days when there where no insico tech. have been in process.So there was a detailed and full errors on long time. This softwares that I've shown in my ppt relates the pharmacological action of drug and chemistry of action the drug molecules( mentioned G PROTIEN in ppt presentation from slide 35 ) .The prostate specific antigen and blood brain barrier graph that could easily plot via these insilico methods and also the relative study of hydrogen bond donors count and logarithm is calculated on basis of these MPA techniues. It not expensive globally either. In case of its multi parametric analysis of action of the drug molecule we can include this technology in various action and reacting drug molecules on different pharmacological action of diff. diseases. This we can implant this software by customising or upgrading these softwares models for maitaining its spectrum broadly within the limits of the scientific and pharmacy drug action . we can also add a new area in which their would be a easy way and layout of calculating the formulation of different drug molecules and its action on which receptors ultimately the effects( for or against both). But these shoulld be genuinely within scientific parameters.

thanks for appreciating my work .