Same Dose does not Fit All : The Promise of Pharmacogenomics
By CHEPURU PRATIBH... - 10/30/2009
(17 votes)
Each of us responds differently to our environment, to the foods we eat, and to the drugs we take. The way we respond to drugs may mean that a drug that is effective for one person may be less effective for another, or drug that is safe for one person may be dangerous for another person—even at the same dosage. Until recently, drugs have been developed with the idea that each drug works pretty much the same in everybody. But genomic research has changed "one size fits all" approach and opened the door to more personalized approaches to using and developing drugs. So, in medicine, one size doesn't fit all. One major reason for this difference is because people inherit variations in their genes. And even slight variations can affect how your body responds to certain medications. Depending on your genetic makeup, some drugs may work more or less effectively for you than they do in other people. Right drug in right dose for right person is what pharmacology is trying since times immemorial. The fact that genes play a role in responsiveness to drug therapy is now known for nearly half a century and giving birth to the term pharmacogenomics . Pharmacogenomics is the study of how an individual's genetic inheritance affects the body's response to drugs. It is sometimes described as "personalized" or "individualized" medicine because it offers the potential to recommend drug treatment based on your individual genetic background. Pharmacogenomics holds the promise that drugs might one day be tailor-made for individuals and adapted to each person's own genetic makeup. Environment, diet, age, lifestyle, and state of health all can influence a person's response to medicines, but understanding an individual's genetic makeup is thought to be the key to creating personalized drugs with greater efficacy and safety. Pharmacogenomics may permit drugs to be tailor-made for individuals and adapted to each person's own genetic makeup. The main objective of this presentation is to elevate the practice of personalized medicine in giving the right treatment to a right person at a right time.
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Can you suggest some of the
Can you suggest some of the means where by pharmacogenomics will help us in fighting with dug resistance associated with anti virals and anti biotic?
Ayush A. Singhal
RPCP, CHANGA
GUJARAT
http://www.pharmainfo.net/ayushsinghal
hello mam, nice and an
hello mam,
nice and an informative presentation...
are there any clinical trials going on for pharmacogenomics...what are the success rate, also mention some egs..
regards,
Sakshi..
Sakshi Agrawal
http://www.pharmainfo.net/sakshi-agrawal
Nice presentation
In what way the pharmmacogenetics of ABC transporters play a role in anticancer drug response.
ABHERI DAS SARMA
http://www.pharmainfo.net/abherids86
Hi Prathiba. That was very
Hi Prathiba.
That was very informative presentation.
could you please list the genes that have been identified till now for causing variation in metabolism of drugs?
Using pharmacogenomics is it possible to specifically identify the reasons for nonresponsiveness of some people to the drugs, such as problem in absorption or distribution or metabolism?
Thank you
Y mahalaxmi
Y Mahalaxmi
http://www.pharmainfo.net/y-mahalaxmi
dear anusha,, Good
dear anusha,,
Good presentation..But one thing
Why is pharmacogenomics not receiving any appreciation? or what are its limitations?? You gave the answer as death occurs..Sigh!!! If you give this answer do patients go with this sort of medicines? Definitely NO right? Then how can we make the genomic medicine more patient friendly??
Sirisha Pingali
www.pharmainfo.net/sirisha
hi, There is an upward trend
hi,
There is an upward trend in the incorporation of pharmacogenomics in clinical trials. Is that true? If yes how?
FDA guidelines
hi,
what are the guidelines offered by FDA on Pharmacogenomic data?
What are the barriers in the
What are the barriers in the pharmacogenomic studies?
K.H.Patel.
My profile link is
http://www.pharmainfo.net/khushbu-hasmukh-patel
question
Is personalized medicine is going to increase gap between rich and poor?
Dear Cheepuru Prathib Does it
Dear Cheepuru Prathib
Does it become very few and rare conditions have limited scope right?
Mr. Dixon Thomas, M. Pharm, M. S., RPh
http://www.pharmainfo.net/pharmacistdixon
can you elaborate the role of
can you elaborate the role of statistics and pharmacogenomics in drug therapy?
Dose calibration and genetic diversity?
Its informative..
Can you comment on dose calibration and genetic diversity? Is is possible to develop common gene based pharmacogenomics?
Dr.Sandeep Bhaskar Kale
http://www.pharmainfo.net/sanykale123
generic tests for developing pharmacogenomic drugs
Dear Pratibha,
What are the generic tests for developing pharmacogenomic drugs?
Thank you
Varsha Bansode
http://www.pharmainfo.net/varsha-bansode
When does a pharmacogenomic test becomes truly clinically usefu
Hello Pratibhanusha,
Clarify my queries like:
1.when does a pharmacogenomic test becomes truly clinically useful?
2.what should be the ideal strategy to be adopted by the health care providers to have a easy access of prescribing drugs based on Pharmacogenomics?
Bhasker
http://www.pharmainfo.net/bhasker
QC and QA of pharmacogenomic drugs
Dear Pratibhanusha,
As your topic says same dose does not fit foe all and i agreed that but you only mentioned that it is difficult to interpret the pharmacogenomic tests then how can one maintain the QC and QA of these products? Is there any specified guidelines?
Dispencing the same dose of drugs to all the patients
hello pratibha
Tell me how will u support your topic.. as presently doctors, or we pharmacists does not prescribe the same dose of a drug to all the patients... wright??
we check for various parameters like age,sex,condition of patient,route of administration before giving a medicine... right??
Then please let me know are there any cases or any places in the world who are dispencing the same dose of drugs to all the patients presently....please answer me with details & proofs...
Shobha Deepthikompella
http://www.pharmainfo.net/shobhadeepthi