Dear Aishwarya,

Any inert long chain fatty acids can be used. But PEG's are mostly preferred

I prefer you calling me Bhavani prasad please..

Regards,

Dear Aishwarya,
First of all i thankyou for your appreciation. To my point of view the disadvantages i came to know are
As we know stealth liposomes has many advantages similarly is has its own disadvantages..
->When administered orally, they undergo rapid metabolism within Gastro intestinal tract itself because of first pass effect.Hence this route is generally less preferred.
The major disadvantage is DOSE DUMPING.

Regards,

Dear Gokul,
Seems like you didn’t go through the topic properly.. These Stealth liposomes come under TARGETTED DRUG DELIVERY SYSTEM which are given only in the form of parenterals like infusions, injections etc,. If you like to see their images you can surf in google imagesdrug names like Dioxil, Ambiosom etc,. As mentioned in ppt.
They are sent only through this route because our cell membrane is made up of large number of phospholipid molecules. As these Stealth liposomes are phospholipid bilayered vesicular membrane entities there is very less possibility for their recognition as a foreign body.
Yes they can be used in the treatment of other diseases also, but so far necessity has come only for the cancer therapy.
Hope you got the answer to your question...and last thing is I prefer you calling me Bhavani prasad or else Prasad ok..

Regards,

Dear Praveen,
i appreciate your question.. here polymerosomes can also be used but they are considered as foreign bodies as they are made up of polymers but where as in case of stealth liposomes there is very less possibility because they are phospholipid bilayered vesicular membrane entities which made up of phospholipid molecules that are already present in our body..hope you understood my point..

Regards,

Thanks Nikilesh and sorry for the late comment.. actuall i was working to figure out the answer to your first part of the question but i couldnt get that still..

The answer for specific site action is--

Liposomes have natural ability to target cancer. The endothelial wall of all healthy human blood vessels are encapsulated by endothelial cells that are bound together by tight junctions. These tight junctions stop any large particle in the blood from leaking out of the vessel. Tumour vessels do not contain the same level of seal between cells and are diagnostically leaky. This ability is known as the Enhanced Permeability and Retention effect. Liposomes of certain sizes, typically less than 400nm, can rapidly enter tumour sites from the blood, but are kept in the bloodstream by the endothelial wall in healthy tissue vasculature.

To my knowledge i think all the cell membranes are made up of Lipids only..

Regards,

Thanks for your comment pratyusha..

here is the answer to your question..

Gangliods are complex, carbohydrate-rich lipids found in cell membranes, most concentrated at the surface of brain cells. It is a compound composed of a glycosphingolipid (ceramide and oligosaccharide) with one or more sialic acids (AKA n-acetylneuraminic acid, NANA) linked on the sugar chain. Most of the known gangliosides differ mainly in the position and number of NANA residues. It is a component of the cell plasma membrane that modulates cell signal transduction events.

Antineoplastic drugs are nothing but..it is the other name for anti-cancer drugs.

Yeah they are marketed..Like Ambiosom, Dioxil etc,. you can find that at the end of ppt..better you go through it once..Hope your doubt got clared now..!!?

Regards,

Stealth mean steal or bringing to pass anything in a secret or concealed manner...
Hope you got the answer

Regards,

ThankQ Aravind...

These Stealth liposomes comes under Targetted transdermal drug delivery systems..and
Pegylated liposomes means the liposomes coated with PEG's i.e Polyethylene glycols..
Hope you are satisfied with this answer..

Regards,