Stealth Liposomes : The Nano-sized particles
Liposome are nano-sized phoSspholipid bubbles with a bilayered membrane structures. Many of the applications of liposome in drug delivery systems have been limited by their short circulation as a result of rapid uptake into recticuloendothelial (mononuclear-phagocyte) system. Hence many approaches were taken to formulate liposome with prolonged circulation (stealth liposome). Polyethylene glycols, gangliosides and glycolipids are used to prepare these liposomes.During last few years, liposome have been used with growing success as pharmaceutical carriers for antineoplastic drugs. Fields of application include lipid-based formulations to enhance the solubility of poorly soluble antitumor drugs, the use of pegylated liposome for passive targeting of tumor tissue. Such formulation and drug targeting strategies enhance the effectiveness of anticancer chemotherapy and reduce at the same time the risk of toxic side effects. Recent advancements in liposomal drugs proved to explore new experimental applications such as gene delivery, cancer therapy.