Influence Of Formulation Factors On In-Vitro Dissolution Of Oxcarbazepine Tablets

Submitted by YVNAGENDRA on Tue, 03/09/2010 - 15:23

The influence of superdisintegrants and method of preparation on dissolution rate of oxcarbazepine was investigated and results were presented here the drug oxcarbazepine belongs to class II category of biopharmaceutical classification system .The tablets formulated with direct compression technique showed better dissolution than wet granulation technique.incorporation of superdisintegrant crosspovidone offered more drug release than the other two super disintegrants sodium starch glycolate,crascormellose .All the formulated tablets satisfied compendial and non-compendial requirements . The dissolution rate followed first order kinetics.

Author: http://www.pharmainfo.net/yvnagendra
Guide: http://www.pharmainfo.net/tegkmurthy

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aravikumar

Wed, 03/10/2010 - 06:23

what are the formulation factors affecting dissolution rate of oxcarbazepine tablets

Averineni Ravi Kumar

Balavishnupriya.M's picture

Balavishnupriya.M

Sun, 03/14/2010 - 15:00

What is the impact of pharmaceutical factors on dissolution rate and bioavailability of tablets prepared by Direct compression? What is the effect of particle size of superdisintegrant on rate of dissolution of tablets prepared by Direct compression?

M.Bala Vishnu Priya

anil kumar appa...

Mon, 03/15/2010 - 11:46

whtat is the purpose of taking 0.3% SLS as dissolution medium?

anilkumar

sowjanya gummalla

Mon, 03/15/2010 - 12:20

what is the formula for carr's index and hausner's ratio? once again please check your slides .
sowjanya gummalla

aukunjv

Sat, 03/20/2010 - 02:08

Why did you chose that medium for dissolution studies?
Madhupharma's picture

Madhupharma

Mon, 03/29/2010 - 05:34

which on eis the best formulation from those you formulated
Madhu
vvummaneni's picture

vvummaneni

Mon, 03/29/2010 - 06:55

Formula for Carr's index & Haussener's ratio??

Vishnu Murthy Vummaneni

bhavya's picture

bhavya

Thu, 04/01/2010 - 06:18

you have used superdisintegrants in your formulation but why you have taken 30-45 min dissolution run time
k.bhavya

sowjanya gummalla

Wed, 04/07/2010 - 06:19

What is the relationship between hardness and disintegration time? In your work, you got that the hardness of F4 formulation is less than the F5 and F6 formulations and disintegration time for F4 is more than the F6. Can you Justify that?
sowjanya gummalla