Chronopharmacokinetics refer to dosing - time (i.e, rhythms-dependant) differences in the absorption, metabolism and elimination of medicat
Chronopharmacokinetics deals with the study of the temporal changes in absorption, distribution, metabolism and elimination and thus takes into account the influence of time of administration on these different steps. All living creatures are endowed with biological clocks that orchestrate, during the 24hrs and other time periods. High amplitude circadian rhythms in disease pathophysiology give rise to day-night patterns in onset and symptoms exacerbation of most acute and chronic medical conditions & diseases. Circadian time dependent differences are also seen in pharmacokinetics of many classes of medications like cardiovascular active drugs, NSAID’s, antidepressants, antihypertensives, local anesthetics, H1 & H2 antagonists etc.
Time variations in the intensities of symptoms or risk of disease, coupled with evidence of circadian rhythms that affects the kinetics, effects, and safety of medications, constitute the rationale for a new pharmacologic approach to treatment. Various technologies such as time-controlled, pulsed, triggered and programmed drug delivery devices have been developed and extensively studied to synchronize medication with the intrinsic biorhythm of the disease.
Chronopharmacokinetics, Circadian rhythms, Chronotherapeutics, Drug Delivery Systems, Technologies.
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Dealing with the different pharmacokinetis aspects and summing up to the elimination part .......
Many factors may influence drug protein binding, these are: temperature, pH, physio-chemical-properties of the drug and plasma concentratio
Hepatic drug metabolism is generally assumed to depend on liver enzyme activity and / or hepatic blood flow both have been shown to be circadian time
Elucidating my topic with the examples of various drugs it follows as;
Temporal variations in biological activity of living system has led to several new disciplines of science. These are :
Chronopharmacology and its aspects