Oral controlled drug delivery systems

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Oral route has been the commonly adopted and most convenient route for the drug delivery .oral route of administration has been received more attention in the pharmaceutical field, because of the more flexibility in the designing of dosage form than drug delivery design for other routes. The oral drug delivery depends on various factors such as type of delivery system , the disease being treated , the patient , the length of the therapy and the properties of the drug . most of the oral controlled drug delivery systems (OCDDS) relay on diffusion , dissolution , or combination of both mechanisms , to release the drug in a controlled manner to the gastro intestinal tract (GIT) . The physico chemical properties include crystal nature, solubility, partition coefficient, intrinsic dissolution; etc.dosage form characteristics are controlled and optimized with respect to the physico chemical properties of the drug and relevantGI environmental factors. Other factors need to be considered are diseased state, the patient compliance & length of therapy. The goal of targeted oral drug delivery systems is to achieve better therapeutic success compared to conventional dosage form of the same drug. This could be achieved by improving the pharmacokinetic profile, patient convenience and compliance in therapy.

Key words:
Oral controlled drug delivery systems, diffusion and dissolution controlled drug delivery systems, osmotically controlled systems

Author: http://www.pharmainfo.net/bhargavialuri

Guide: http://www.pharmainfo.net/prasanthi

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Comments

Swathi Gondhi's picture

can i know why drugs which are absorbed by carrier mediated transport are not suitable for controlled delivery

swathi.G

Bhargavialuri's picture

f the drug is absorbed by carrier mediate transport, the absorption of the drug is depend on the number of carriers available, if the carriers are saturate absorption will be hindered , so though the drug is released from the dosage form it can't be absorbed into systemic circulation -hence we can't go for controlled release formulation for drugs which are absorbed by carrier mediated transport. references: Encyclopedia of controlled drug delivery bhargavi

bhargavi

Vishnu Murthy Vummaneni's picture

what are plastic matrices?

Vishnu Murthy Vummaneni

Averineni Ravi Kumar's picture

what are the advantages of oral controlled drug delivery systems

Averineni Ravi Kumar

Bhargavialuri's picture

the following are the advantages of oral controlled drug delivery systems : 1. improved patient compliance 2. reduced side effects 3. less fluctuating plasma drug level 4. better sability of drug improved patient compliance is due to, reduced frequency of administration reduced side effects is due to , low dose . less fluctuating plasms drug level is maintained with controlled drug delivery systems, because the drug is slowly released from the dosage form continuously and maintains the constant blood level, where as in case of immediate release dosage form, the plasma level was raised immediately, once the Cmax is reached it will fall down, if we take the dose again the concentration will be raised up, it is fluctuating, whereas in case of controlled drug delivery system, constant plasma level is maintained .

bhargavi

Anil kumar appapurapu's picture

what is the ideal partical size of drugs if we want to administer by nasal drug delivary system?

anilkumar

Bindu's picture

what is the better route of drug delivery among you have explained
Pooja Chowdary's picture

which is the most preferable route amoung all which you have mentioned?

pooja