Magnetic Targeted Carriers - Targeted drug delivery system

Submitted by hemanthakumar on Tue, 10/19/2010 - 00:39

Targeted drug delivery is a method of delivering medication to a patient in a manner that increases the concentration of the medication in some parts of the body relative to others.

It concentrates the medication in the tissue of interest, reducing the relative concentration of the medication in the remaining tissues. Thus improves Therapeutic efficacy by reducing side effects. Targeted drug delivery can be used to treat most dreadful diseases live Cardiac, DM and Cancers. MTCs are Micro particles, composed of metallic iron and activated carbon, which serve as delivery vehicles for the site specific targeting, retention and release of drugs in a controlled and targeted manner. There are different types of MTC and they work with different mechanism and have wide range of application.

The present presentation includes
• Introduction about Targeted Drug Delivery
• Advantages & Uses
• Introduction about Magnetic Targeted drug delivery system or Magnetic targeted carriers (MTC)
• Types of MTC
• MTC mechanism
• Factors influencing accumulation of MTC
• Benefits & Drawbacks of MTC
• Applications of MTC
• Characterization of MTC

Key words: Targeted Drug Delivery System , MTC, Liposomes, Nanoparticle

Profile page link of the author: http://www.pharmainfo.net/hemanthakumar

Profile page link of the guide: http://www.pharmainfo.net/sbrito-raj

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Comments

sirisha's picture

sirisha

Wed, 10/20/2010 - 05:27

hello hemanth This area is completely unknown to me. Well your explanation is satisfactory. Just few queries.. Of all the types of MTCs which one is used predominantly and why?? When did this MTC came into light?? What are other applications of MTC apart from tumor diagnosis?? thank you

Sirisha Pingali

http://www.pharmainfo.net/sirisha

s.brito raj's picture

s.brito raj

Sun, 10/24/2010 - 10:19

mtc liposome can be used predominantly because while comparing to other formulation , design of lip[osomes is somewhat economical and ease also.the mailn application of MTC is targeting the abnormal cells instead of accumulation of drug in normal cells as other formulation. so main thin toxicity is reduced
S.Brito Raj Asst Professor Department of Pharmaceutics Sri Venkateswara College of Pharmacy Chittoor (AP) India
abhishekrathi's picture

abhishekrathi

Wed, 10/20/2010 - 19:16

Nice presentation Hemanth, I just have few doubts related to use of this delivery system 1.As the concentration of Magnetite is quite high,there might be chances of its interaction with the drug which is going to be incorporated in that delivery system,if it is there then what should be the measures to be taken? 2.Is there any toxicity of the magnetite used,as it is a metal in nature. Thank You. Abhishek Rathi http://www.pharmainfo.net/abhishekrathi http://www.pharmainfo.net/majumdarshiv
Abhishek Rathi
s.brito raj's picture

s.brito raj

Sun, 10/24/2010 - 11:37

Dear Sir, Thanks for your valuable comments regarding the first question you have asked , it will take some more days . but for your second question you can refer the below link http://www.nanowerk.com/spotlight/spotid=462.php
S.Brito Raj Asst Professor Department of Pharmaceutics Sri Venkateswara College of Pharmacy Chittoor (AP) India
abhishekrathi's picture

abhishekrathi

Wed, 10/27/2010 - 14:55

Thank you Sir.... i will look at the reference provided by you.... Regards
Abhishek Rathi
ketanchaudhari's picture

ketanchaudhari

Thu, 10/21/2010 - 09:56

can u please elaborate more on the cancer treatment using magnetic targeted drug delivery

KETAN CHAUDHARI

s.brito raj's picture

s.brito raj

Sun, 10/24/2010 - 10:14

it is mainly created for cancer only because by this formulation we can an\ble to target the abnormal cell and destroy it.
S.Brito Raj Asst Professor Department of Pharmaceutics Sri Venkateswara College of Pharmacy Chittoor (AP) India
viragshah's picture

viragshah

Thu, 10/21/2010 - 13:56

Hello, Hemanth As you have told that MTS can be used in Cardiovascular disease, can it be possible to administered MTS to patient who has been fitted with peacemaker device. Can you elaborate and explain me this in details. Regards Virag Shah http://www.pharmainfo.net/viragshah
s.brito raj's picture

s.brito raj

Sun, 10/24/2010 - 10:12

it is not possible to use for the patient with pacemaker due to the interaction of magnetic substance with the material of the pacemaker.on applying the magetic field for targetting it will interfer with the artificial electric impulse created by the electrode of pacemaker
S.Brito Raj Asst Professor Department of Pharmaceutics Sri Venkateswara College of Pharmacy Chittoor (AP) India
hemasree's picture

hemasree

Thu, 10/21/2010 - 14:46

hi hemanth, your topic is new to me . I have some queries.Apart from ferrofluids are there any other materials which can be used as magnetite.In what way it is used in field of biosciences can you give any example in that field where MTC is used

G.N.S.Hemasree

sailesh's picture

sailesh

Fri, 10/22/2010 - 04:57

Nice presentation. Can you please tell me about the strength of magnetic field that has to be applied? What is the maximum limit that can be used? Is there any possibility of disturbances in physiological system due to the applied magnetic field?
G.Sailesh http://www.pharmainfo.net/sailesh

anil kumar appa...

Sat, 10/23/2010 - 03:26

Abstract: "MTCs are Micro particles, composed of metallic iron and activated carbon, which serve as delivery vehicles for the site specific targeting", in this connection pls write the comments on drug delivery by this method for the drugs of having 1. oxidizing properties (iron problem in such cases) 2. Unpaired electrons(is there any need for iron addition for attaining magnetic property) 3. Low therapeutic index. 4. give me list of drugs unsuitable for this type delivery? 5. what is the role of activated carbon?

anilkumar

Arun Kumar Palle's picture

Arun Kumar Palle

Sat, 10/23/2010 - 12:22

Very nice presentation. You have mentioned the magnetic resealed erythrocytes in you presentation can you please specify me some of the parameters while selection like Age of RBC How much amount of substance can be incorporated. effect of magnetism on Fe group of hemoglobin. effect on osmotic balance. If resealed erythrocytes are not utilized as per the requirement then how will be its degradation.
sandeepreddy's picture

sandeepreddy

Sun, 10/24/2010 - 05:39

nice presentation 1) is this magnetic nanoparticles are used intreatment of asthma...? 2)how much quantity of drug u incorporate in case of magnetic erythrocytes? 3)in case of magnetic emulsions what is the globule size? 4)how does the magnetic erythrocytes tolerate the body defence mechanism?

anil kumar appa...

Mon, 10/25/2010 - 13:57

power point: good work of presentation and the questionnaires slide no. 7: what is the mechanism of release over there? slide no. 8: when we are using external magnetic field , is the blood flow effects the accumulation of MTC? slide no. 9: is there any dose dumping as the drug delivered directly to blood capillaries? slide no.11: what are the selection parameters for the PSEP and CSE?

anilkumar

pooja.chowdary's picture

pooja.chowdary

Tue, 10/26/2010 - 16:14

Hello, can you please explain me briefly about about the administration of MTCs?
pooja
abhishekrathi's picture

abhishekrathi

Wed, 10/27/2010 - 17:30

Dear Hemanth, I want to know that could the magnetic carriers like microspheres,liposomes, nanoparticles,emulsions be used in case of brain disorders and diseases for delivery of drugs?
Abhishek Rathi
bharathreddy's picture

bharathreddy

Thu, 10/28/2010 - 00:31

hello sir how can I download this presentation
Bharath Hi friends I request u to sms "ON Pharmahouse" to 9870807070. This gives u trusted information about Pharmacy.I love Pharmacy and I beleive in the caption "Pharamcy saves your life" and also "Hard Work Never Goes waste".
Arun Kumar Palle's picture

Arun Kumar Palle

Thu, 10/28/2010 - 11:52

Can you please specify me the strenght of magnetic field can be used? If so can you please specify me the instruments
Arun Kumar Palle's picture

Arun Kumar Palle

Thu, 10/28/2010 - 11:55

Can you please say me how could the side effects or adverse effects can be reduced? I yes then can you say me any drug reported so?
Arun Kumar Palle's picture

Arun Kumar Palle

Thu, 10/28/2010 - 12:00

You have said that this system can be adapted to any part of body? Is this system has the capacity to treat any foetus related problems? Do it can Cross BBB, Placenta barrier, Blood testis barrier?
Arun Kumar Palle's picture

Arun Kumar Palle

Thu, 10/28/2010 - 12:04

what is the effect of Zeta potentioal in emulsion form? Can you please specify any marketed products of this type? Can you please give me any information about Different types of polymers ligand used for this system?
Arun Kumar Palle's picture

Arun Kumar Palle

Thu, 10/28/2010 - 12:06

How this system is more beneficial than recent robotic technique of drug delivery?
pooja.chowdary's picture

pooja.chowdary

Thu, 10/28/2010 - 14:57

Can you tell me the real advantage of MTCs
pooja
pooja.chowdary's picture

pooja.chowdary

Thu, 10/28/2010 - 15:13

In which case does these MTCs have significant use??
pooja
pooja.chowdary's picture

pooja.chowdary

Thu, 10/28/2010 - 15:21

Hi, Can this delivery system be used in the cancer treatment? Does it have advantage over the other delivery systems in that concern. Regards,
pooja
sandeepreddy's picture

sandeepreddy

Fri, 10/29/2010 - 07:33

hello till now u didnt give reply to my ouestions ..... hemanth can you give any example of adverse drug reaction by MTC
shafichamp's picture

shafichamp

Sat, 10/30/2010 - 09:32

hi..... can you please explain me reverse micelle mechanism in the synthesis of magnetic nano particles...??
shafi ..
pooja.chowdary's picture

pooja.chowdary

Sat, 10/30/2010 - 10:36

can you explain me about the mechanism of magnetic drug targetting?
pooja
pooja.chowdary's picture

pooja.chowdary

Sat, 10/30/2010 - 10:40

can these MTCS are used in the treatment of metastatic liver cancer?
pooja
Arun Kumar Palle's picture

Arun Kumar Palle

Sun, 10/31/2010 - 08:43

Can you explain me about Resealed erytrocytes usage in magnetism during Anemic condition, leukemia conditions?
Arun Kumar Palle's picture

Arun Kumar Palle

Sun, 10/31/2010 - 08:46

Can this system be useful in Parkinsonism and Depression disorders of brain? If so what is the mechanism? Can you give me any marketing products?
Arun Kumar Palle's picture

Arun Kumar Palle

Sun, 10/31/2010 - 08:50

You have not yet answered to my question about the strength of magnetic field used waiting for your reply? What is the appropriate treatment can you suggest for treatment of rheumatoid arthritis whether magnetic method or nay other
pooja.chowdary's picture

pooja.chowdary

Sun, 10/31/2010 - 17:17

can you explain me briefly about how cancer is treated by using MTCS?
pooja

Harsh bansal

Mon, 11/01/2010 - 14:34

hello hemant i have a query you told that MTS can be used in Cardiovascular disease, can you explain it in detail .... thank you

harsh bansal

pooja.chowdary's picture

pooja.chowdary

Mon, 11/01/2010 - 18:35

what type of drugs are suitably used in this type of delivery?
pooja
pooja.chowdary's picture

pooja.chowdary

Thu, 11/04/2010 - 16:53

can you explain me in brief about magnetic liposomes?
pooja
pooja.chowdary's picture

pooja.chowdary

Fri, 11/05/2010 - 06:49

can you explain me abt the hurdles of this system?
pooja
abhishekrathi's picture

abhishekrathi

Sat, 11/06/2010 - 17:07

Dear Hemanth, Que.As the concentration of Magnetite is quite high,there might be chances of its interaction with the drug which is going to be incorporated in that delivery system,if it is there then what should be the measures to be taken?
Abhishek Rathi
abhishekrathi's picture

abhishekrathi

Sun, 11/07/2010 - 02:58

Dear Author, I have query regarding drugs. Could the class III and class IV drug's permeability be enhanced through this system? Thanks
Abhishek Rathi

Harsh bansal

Sun, 11/07/2010 - 15:14

hello hemant its last day today... its very nice to meet u through this competition your presentation is nice all the best for your future thank you

harsh bansal

pooja.chowdary's picture

pooja.chowdary

Sun, 11/07/2010 - 16:29

ALL THE BEST....
pooja
subhashis.shcp's picture

subhashis.shcp

Mon, 11/08/2010 - 04:13

your presentation is nice......is there any side effect of magnetic targeted drug delivery system?
subhashis
abhishekrathi's picture

abhishekrathi

Mon, 11/08/2010 - 05:18

Dear Author, All the best. Its been a very nice experience. It was a really awesome and knowledgeable. Thanks & Regards
Abhishek Rathi
Arun Kumar Palle's picture

Arun Kumar Palle

Mon, 11/08/2010 - 07:01

Dear Author Iam very much glad to meet you through this competition. And wish you all the best with regards Arun kumar palle & V.R.M.Gupta
shafichamp's picture

shafichamp

Mon, 11/08/2010 - 13:22

hi.. all the best 2 all...
shafi ..
usha sree musunuri's picture

usha sree musunuri

Mon, 12/27/2010 - 10:32

can u breifly tel me about the mechanism involved in preparation of magnetic resealed erythrocytes ?does this include entrapment of magnetite also?

usha..