Uddhav S. Bagul
Mouth Dissolving Tablets
conventional tablets cannot be swallowed with out water. However, water or any other fluid is needed, by the patients, in most of the cases to swallow the capsule or tablet. The difficulty in swallowing, more commonly termed as dysphagia, is apparent in patients of all age groups, especially the pediatrics and geriatrics. The result is a high incidence of non compliance and ineffective therapy. In case of patients who are mentally ill, uncooperative, nauseated patients and those with acute episodes of coughing or asthma the time of response should be very rapid which indicates that the drug should be absorbed into the systemic circulation as early as possible.
All the foresaid problems led to the development of an oral novel drug delivery system called ‘The Mouth Dissolving Tablets’ are defined as the solid dosage forms that dissolves or disintegrates quickly in the oral cavity, resulting in solution or suspension form without the need of water for the administration. They are also known as Rapid mouth dissolving tablet,Rapid melt, rapid dissolve, fast dissolve and quick disintegrating tablets. Thus, the mouth dissolving tablets have a significant impact on the overall patient compliance. Some Oral dissolving tablets can be given, to psychiatric patients, in the crushed form added in tea, there by decreasing the refusal rate by psychiatric patients for the administration of oral dosages.
The rapid dissolving tablets can be manufactured by three major technologies.
1) The conventional tablet processes with modifications
2) Freeze drying methods
4)cotton candy process.
10)moulding and etc..
The present article is a comprehensive review which focuses on the significance of mouth dissolving dosage forms and the techniques available for their manufacturing.
Key words: Rapid melt, OD tablet technologies, Melt-in-mouth-tablets
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Profile page link of the guide: http://www.pharmainfo.net/ramamohan
1.4.2 Tablets used in the oral cavity (1-3)
Despite of tremendous advancements in drug delivery, the oral route remains the perfect route for the administration of therapeutic agents because the low cost of therapy and ease of administration lead to high levels of patient compliance.
Recently, fast-dissolving drug delivery systems have started gaining popularity and acceptance as new drug delivery systems, because they are easy to administer and lead to better patient compliance. Usually, elderly people experience difficulty in swallowing the conventional dosage forms (tablets, capsules, solutions and suspensions) because of tremors of extremities and dysphagia. Fast-dissolving drug delivery systems may offer a solution for these problems. Fast dissolving drug delivery (FDDS) can be achieved by various conventional methods like direct compression, wet granulation, moulding, spray drying, freeze drying, and sublimation
INTRODUCTION Many pharmaceutical dosages are administered in the form of pills, granules, powders, and liquids.
Orally disintegrating tablets also called as fast dissolving or mouth dissolving tablets are such kind of dosage forms which when placed in mo
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