Mouth Dissolving Tablets

Sponsored Links

conventional tablets cannot be swallowed with out water. However, water or any other fluid is needed, by the patients, in most of the cases to swallow the capsule or tablet. The difficulty in swallowing, more commonly termed as dysphagia, is apparent in patients of all age groups, especially the pediatrics and geriatrics. The result is a high incidence of non compliance and ineffective therapy. In case of patients who are mentally ill, uncooperative, nauseated patients and those with acute episodes of coughing or asthma the time of response should be very rapid which indicates that the drug should be absorbed into the systemic circulation as early as possible.
All the foresaid problems led to the development of an oral novel drug delivery system called ‘The Mouth Dissolving Tablets’ are defined as the solid dosage forms that dissolves or disintegrates quickly in the oral cavity, resulting in solution or suspension form without the need of water for the administration. They are also known as Rapid mouth dissolving tablet,Rapid melt, rapid dissolve, fast dissolve and quick disintegrating tablets. Thus, the mouth dissolving tablets have a significant impact on the overall patient compliance. Some Oral dissolving tablets can be given, to psychiatric patients, in the crushed form added in tea, there by decreasing the refusal rate by psychiatric patients for the administration of oral dosages.
The rapid dissolving tablets can be manufactured by three major technologies.

1) The conventional tablet processes with modifications
2) Freeze drying methods
3)Direct compression.
4)cotton candy process.
5)spray drying
6) sublimation.
7)mass extrusion
8)mouldind
9)nanonization
10)moulding and etc..

The present article is a comprehensive review which focuses on the significance of mouth dissolving dosage forms and the techniques available for their manufacturing.

Key words: Rapid melt, OD tablet technologies, Melt-in-mouth-tablets
Profile page link of the author: http://www.pharmainfo.net/poojachowdary
Profile page link of the guide: http://www.pharmainfo.net/ramamohan

Comments

Anil kumar appapurapu's picture

1. suggest the suitable technique for prepation of MDT's for the drug of having a. moisture sensitive b. high porosity c. less stability 2. when will be the coating or encapsulating technique is used for MDT as they delay drug solubility and dissolution?

anilkumar

Pooja Chowdary's picture

1)Freeze drying and sublimation are the most suitable techniques for preparation of MDTS having high porosity,moisture sensitivity,less stability.

pooja

Anil kumar appapurapu's picture

1.what is the mechanism of drug release from cotton candy technology prepared MDT's? 2.in granulation technology what are the main advantage of flash tab than wowtab? 3. Example for bulking agents used in direct compression for MDT's?

anilkumar

Pooja Chowdary's picture

Hello anil, 1)Genarally the mechanism of drug release will be similar for all methods in mouth dissolving tablets. The cotton candy process is a unique spinning mechanism to produce floss-like crystalline structure, which mimic cotton candy. Cotton candy process involves formation of matrix of polysaccharides or saccharides by simultaneous action of flash melting and spinning. The matrix formed is partially recrystallized to have improved flow properties and compressibility. The candy floss matrix is grinded and blended with drug and excipients and then compressed to ODT. This process is more helpful for high doses of drug and also increse mechanical strength of tablet. But high temperature process limits the use of this process. 2)In the flash tab technology combination of low mouldability saccharides is used to get a rapidly melting strong tablet. And tablets prepared by this systen consists of micro crystals which enables fast dissolution of drug. Drug micro granules may be prepared by using conventional techniques like,coeservation,encapsulation and etc... 3)Mannitol,lactose and etc are the examples for bulking agents in direct compression method of MDTS.

pooja

Abhishek Rathi's picture

Dear Author, I want to know that could all BCS class drugs be formulated as Mouth Dissolving Formulation. If yes,then how the solubility(Class II & IV) and permeability(III & IV) is increased in case of these drugs.

Abhishek Rathi

Abhishek Rathi's picture

Which are the marketed preparations available as mouth dissolving tablets?

Abhishek Rathi

Pooja Chowdary's picture

Here are the some of the marketed preparations of mouth dissolving tablets: 1)ZYPREXA ZYDIS 2)ZYROF MELTAB 3)ZOFRAN ODT 4)MAXALT MLT 5)CLARITIN REITAB 6)PEPSID RPD

pooja

Sudha Thamarapalli's picture

Hello pooja, In lyophilization techniques thesolution or suspension is directly filled in final packages and then subjected to sublimation. there is no compression step here. How can you say that the dry form obtained is a tablet? it can also be a dry powder. Regards, SUDHA.T

Regards,

Sudha.T

Pooja Chowdary's picture

Actually,in freeze drying process(lyophillization) water is sublimed from the product after it is frozen. The process of lyophillization involves the following steps: 1)bulk preparation of an aqueous drug solution or suspension and its subsequent precise dosing into pre- formed blisters. It is the blister that actually forms the tablet shape and is, therefore, an integral component of the total product package. 2)passing the filled blisters through a specially designed cryogenic freezing process to control the ultimate size of the ice crystals which ensures that the tablets possess a porous matrix to facilitate the rapid disintegration property. These frozen units are then transferred to large-scale freeze dryers for the sublimation process, where the majority of the remaining moisture is removed from the tablets. 3)sealing the open blisters using a heat-seal process to ensure stability and protection of the product from varying environmental conditions. Reference: www.scipharm.at

pooja

Harsh bansal's picture

hello pooja its last day today... its very nice to meet u through this competition your presentation is nice all the best for your future thank you harshbansal23@rocketmail.com

harsh bansal

Abhishek Rathi's picture

Dear Author, All the best. Its been a very nice experience. It was a really awesome and knowledgeable. Thanks & Regards

Abhishek Rathi

Pooja Chowdary's picture

Thank you. wish u too a very good luck.

pooja

Sandeep Reddy's picture

once again all the best
Pooja Chowdary's picture

Thank u Mr.sandeep Reddy.

pooja

Arun Kumar Palle's picture

Dear Author Iam very much glad to meet you through this competition. And wish you all the best with regards Arun kumar palle & V.R.M.Gupta
Pooja Chowdary's picture

Thank you Arun. wish u a very good luck.

pooja

SS Md Shafi's picture

HI.. ALL THE BEST 2 ALL...

shafi ..

Wasim Raja's picture

Hi, Let me know the exact pharmacokinetics of this mouth dissolving tablets ? and it will be highly appreciable if you could give some market available products of this type of formulation and explain in detail about their advantages over the conventional formulation

Wasim Raja.S Asst.Professor Department of Pharmacy Practice Sri Venkateswara College of Pharmacy, Chittoor

Gopal Gandhi's picture

hi...pooja their is problem arises during formulation of mouth dissolving tablet friability is high as compare to convectional tablet.so what should we do to improved % friability of tablet.

Gopal S. Gandhi M.Pharm (Pharmaceutics) Agnihotri college of Pharmacy, Wardha.

RAGHAVENDRA KUMAR GUNDA's picture

hai pooja, I wants to know about the dissolution criteria for MDTs as per INVITRO EVALUATION. what is the type of apparatus used for doing this experiment and composition same as SIF(SIMULATED INTESTINAL FLUID) PH6.8. CLARRIFY WITH FULL DETAILS. ANY OTHER SPECIAL ANCILLARY FITTING IS NEEDED FOR DOING THIS(LIKE MAGNETIC STIRRER HOT PLATE ETC) TEMPERATURE MAINTENANCE VOLUME AND COMPOSITION OF DISSOLUTION MEDIUM ETC

Raghavendra Kumar Gunda

Sandhya Sampathirao's picture

can u kindly mail me a copy to address sandhya.pharma10@gmail.com !

sandhya.s

Shishira Reddy's picture

hi sir/madam,

ur ppt is very nice and informative.

can u plz send that 2 my mail id

thnx in advance

shishira

Pages