Administered a siRNA in cancer treatment

Dear Pratyesh,
U have given information regarding a new mode of cancer therapy. As i am a Bionanotech student i want to give some more information regarding ur talk. Not only RNA delivery, also controlled drug delivery is possible with these kinds of micro and nanoparticles delivery technology. In recent years, polymer microparticles containing magnetite nanospheres have found application in different areas of biological/medical research and therapy. These particles have been used as contrasting agents for magnetic resonance imaging scans, for separation of biological products, and also more importantly for site-specific delivery of drugs using external magnetic fields. As ur talk, in the administration of antineoplastic agents used in systemic chemotherapy, by targeting a local tumor site using an external magnetic field, magnetic drug carriers can be used to allow higher tumor drug concentrations to be attained while reducing the systemic toxicity.
Delivery systems based on pH-responsive nanoparticles can control the release of rapidly metabolized drugs and/or have the ability to protect sensitive drugs, thereby making them ideal candidates for drug delivery applications.With a single drug delivery
system, drug release for two different drugs loaded via two distinctly different interaction
forces was demonstrated in an article. The drugs they used to demonstrate their work was Procaine hydrochloride, a local anesthetic used in dental surgery, and imipramine hydrochloride, an anti-depressant.These drugs are often sensitive to the physiological environments and should be protected using a delivery vehicle.
Release systems based on the controlled swelling of nanoparticles (like nanogels) satisfy such requirements. As a result, the development of nanoparticles (nanogels) that are responsive to pH or ionic strength or any other physiologcal stimuli is an interesting field of research on the development of specific drug carriers. Such systems, which are useful inpulsed drug delivery, normally undergo changes in their structures or intra-molecular interactions due to external stimuli. There are two goals that should be satisfied in the design of an efficient drug delivery system namely:
1. efficient binding of drugs to the polymeric matrix and release of the drugs
in a controlled manner,
2.. ability to release drugs through a local or externally applied trigger by
changing the binding affinity between the drug and polymeric matrix.

Hope i have given some valuable information regarding nanoparticles for drug delivery. And, I ll be happy to get more comments on my talk. Thanks.