Self-Emulsifying Drug Delivery System

pratyesh's picture
Submitted by Pratyesh m. Somani on Fri, 08/01/2008 - 10:03.
in
0

Self-emulsifying drug delivery system (SEDDS) is type of emulsion that has higher oral bioavailability for poorly absorbed drugs. This system is ideally isotropic mixture of oil and surfactant that form emulsion on mixing with water with little or no energy at all.  Poorly absorbed drugs like hydrophobic drugs are dissolved in the system.

 

After administrating the drug, which is mixed with the system, emulsion is formed in the G.I. tract by self-emulsification. This system increases the bioavailability of drug so low amount of drug will fulfill the required effect. So it can also be needful for those potent drugs, which are to be administered in low dose.

 Example of such drugs, which is to be administered with SEDDS, is cyclosporin A.

Surly..

pratyesh's picture
Submitted by Pratyesh m. Somani on Tue, 08/26/2008 - 19:58.

I will surly try to expand those details with the good explanation and drugs.

Pharmacist

Interesting topic covered!

eswar's picture
Submitted by eswar on Sat, 08/02/2008 - 00:06.

Dear Pratyesh,
It is really a nice topic and if you observe now-a-days it became a hot topic in academic research. Lipid based systems are gaining importance day-by-day.
Even one of my friend got good response for his presentation on SMEDDS (Self-Micro Emulsifying Drug Delivery Systems) at AAPS Exposition.
If possible try to extend the blog with some beautiful examples of the ingredients used to prepare these systems, this will be helpful to the readers.
Good Luck.
{eswar} G.S.N.Koteswara Rao