Problems in Tablet Manufacturing

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An ideal tablet should be free from any visual defect or functional defect. The advancement and innovations in tablet manufacture have not decreased the problems , often encountered in the production , instead have increased the problems , mainly because of the complexities of tablet presses; and / or the greater demands of quality. An industrial pharmacist usually encounters number of problems during manufacturing. Majority of visual defects are due to inadequate fines or inadequate moisture in the granules ready for compression or due to faulty machine setting. Functional defects are due to faulty formulation. Chipping Sticking Picking Binding Capping Lamination Mottling Double impression Key words: capping, mixing, granules, punches, compression, cracking.. Author :http://www.pharmainfo.net/nagesh-pavuluri Guide : http://www.pharmainfo.net/prasanthi

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Comments

Vishnu Murthy Vummaneni's picture

consider the punches(both upper & lower)and the die (made of stainless steel) having rust on their surfaces are used during manufacturing of tablets without noticing. what problems/defects one can expect during compression of tablets.?

Vishnu Murthy Vummaneni

Averineni Ravi Kumar's picture

what are the problems faced in manufacturing of ayurvedic tablets.

Averineni Ravi Kumar

anil kumar appapurapu's picture

what is bridging and rat-holing and its importance in manufacturing tablets?

anilkumar

Kishore's picture

what problems are generally seen when inner rings are developed in dies

G. KISHORE., Associate Professor, VIGNAN PHARMACY COLLEGE, GUNTUR, Leading Tutor for GPAT & NIPER- HYDERABAD ACADAMY

Bhavya's picture

what are the in process quality control tests for tablets?

k.bhavya

Bindu's picture

what are the solvents used in orange peel effect to decrease the viscosity of solution?