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Principal Research Scientist I -WYETH-USA- API Pearl River, NY

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Plan and implement projects with minimal supervision. Conduct laboratory work aimed at developing processes for the manufacture of pharmaceutical ingredients (APIs). Solve problems that arise during process optimization activities. Prepare technical reports and technology transfer documents for technology transfer to external 3rd party plant operations. Support preparation of API for late stage development and manufacturing.

Job Responsibilities
Evaluate and optimize synthetic routes for APIs.
Propose alternate synthetic options
Develop robust conditions for scale up of chemical reactions
Identify process by-products and devise appropriate in-process tests.
Analyze mechanistic interpretation of competing process pathways
Keep abreast of breaking technical developments in organic chemistry, process development, automated reaction screening.
Provide technical reports and technical transfer documents.
Satisfactorily complete all cGMP/cGLP and safety training in conformance with Departmental requirements.

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Glitazones increasing fractures:

Submitted by sailajabyrisetty on Mon, 04/23/2007 - 04:52.

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I read this article from one of the pharmacy news letter.

There is concern about fractures in women using AVANDIA (rosiglitazone) and ACTOS (pioglitazone). Health Canada is warning about use of these medications. Women, whoever is using these drugs, seem to get more fractures of the arm, hand, ankle, and foot...but not hip or spine so far. Similar risk is not found in men it seems. Health Canada is recommending to tell women that this doesn't prove that glitazones cause fractures, but suggest monitoring bone density in women who are at risk for fractures or falls.