<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="6.x">Drupal-Biblio</source-app><ref-type>12</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Damanjeet ghai, Shyamala Bhaskaran, Gurpreet Singh, Mamta Sood</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Extrusion Spheronization as a drug delivery system: A technical note</style></title></titles><keywords><keyword><style  face="normal" font="default" size="100%">controlled release</style></keyword><keyword><style  face="normal" font="default" size="100%">Extrusion-Spheronization</style></keyword><keyword><style  face="normal" font="default" size="100%">multiparticulates</style></keyword><keyword><style  face="normal" font="default" size="100%">Pellets</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2009</style></year></dates><abstract><style face="normal" font="default" size="100%">Compared to single-unit dosage forms, oral multiparticulate drug-delivery systems (e.g. pellets, granules) offer biopharmaceutical advantages in terms of a more even and predictable distribution and transportation in the gastro-intestinal tract. There are different pelletizations and granulation techniques available to prepare drug loaded spherical particles or granules. Extrusion Spheronization is one of them and utilized in formulation of beads and pellets. Limitations related to bioavailability and site specific drug delivery can be over come by this technique. Today this technology has gained attention because of its simple and fast processing. Extrusion spheronization is widely utilized in formulation of sustained release, controlled release delivery system. This article discusses about the extrusion spheronization process and its application in pharmaceutical industry as well as focuses on modified process called as melt extrusion process utilized for formulation of sustained release tablets, transdermal delivery system and transmucosal delivery system in pharmaceutical industry.</style></abstract><call-num><style face="normal" font="default" size="100%">+91-9417495575</style></call-num><notes><style face="normal" font="default" size="100%">Article is based on Extrusion-Spheronization Technology.</style></notes></record></records></xml>