<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="6.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Himanshu Gupta</style></author><author><style face="normal" font="default" size="100%">Aarti Sharma</style></author><author><style face="normal" font="default" size="100%">Birendra Shrivastava</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Pluronic and chitosan based in situ gel system for periodontal application</style></title><secondary-title><style face="normal" font="default" size="100%">Asian Journal of Pharmaceutics</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">chitosan 150KD</style></keyword><keyword><style  face="normal" font="default" size="100%">In situ gel</style></keyword><keyword><style  face="normal" font="default" size="100%">periodontal anaesthesia</style></keyword><keyword><style  face="normal" font="default" size="100%">pluronic F-127</style></keyword><keyword><style  face="normal" font="default" size="100%">prilocaine</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2009</style></year><pub-dates><date><style  face="normal" font="default" size="100%">04/2009</style></date></pub-dates></dates><publisher><style face="normal" font="default" size="100%">MedKnow publication</style></publisher><volume><style face="normal" font="default" size="100%">3</style></volume><abstract><style face="normal" font="default" size="100%">Aim of this paper is to develop and evaluate a physiologically activated in situ gel for local periodontal application. The gel, when at formulation pH and temperature (pH 6, 25°C) will be at liquid form which will be converted to gel at body pH and temperature (pH 7.4, 37°C) showing ease of administration and prolonged duration of action. Chitosan which was both mucoadhesive as well as pH simulative polymer was used in combination with pluronic F-127 which is a temperature simulated gelation polymer. Prilocaine hydrochloride was used as model drug to check the efficacy of the developed in-situ gel system. Different combination of chitosan and pluronic F-127 were tested and final combination of 0.5% w/v and 10% w/v of chitosan and pluronic F-127 respectively were selected and further evaluated for parameters like physicochemical properties, viscosity, gelation pH, gelation temperature, in-vitro release, sterility testing and stability testing. The system thus developed was found to be clear and have good viscosity with prolonged release at pH 7.4 and 37°C. The formulation can be easily packaged and sterilized with method employed. As per ICH guidelines gel was found to be stable and a shelf life of 2years was assigned to the formulation.</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue></record></records></xml>