<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sandeep S Sonawane</style></author><author><style face="normal" font="default" size="100%">Paraag S. Gide</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">A validated Stability indicating method  for Ranolazine</style></title><secondary-title><style face="normal" font="default" size="100%">INDIAN DRUGS</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">forced degradation studies</style></keyword><keyword><style  face="normal" font="default" size="100%">HPLC</style></keyword><keyword><style  face="normal" font="default" size="100%">Ranolazine tablets</style></keyword><keyword><style  face="normal" font="default" size="100%">Stability-indicating</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2009</style></year><pub-dates><date><style  face="normal" font="default" size="100%">05/2009</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">46</style></volume><pages><style face="normal" font="default" size="100%">426</style></pages><abstract><style face="normal" font="default" size="100%">The present paper describes development of stability – indicating RP – HPLC method for ranolazine in the presence of its degradation products, generated from forced degradation studies. Ranolazine was subjected to forced decomposition under acidic, basic, hydrolytic, photolytic and oxidative conditions. Successful separation of drug from degradation products formed under stress conditions was achieved on a C 18 column using 0.02 M potassium phosphate buffer (pH 2.0): acetonitrile (60:40 V/V) as a mobile phase at a flow rate of 1mL/min. The detection was carried out at 225 nm. The method was validated for linearity, range, accuracy, precision and selectivity. The developed method can be used to evaluate quality of regular production samples and also to test stability samples of ranolazine tablets. </style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue></record></records></xml>