0 Buchi N. Nalluri K.P.R. Chowdary K.V.Ramana Murthy V. Satyanarayana A.R. Hayman G. Becket 2005 Journal of Inclusion Phenomena and Macrocyclic Chemistry 53 103 Inclusion Complexation, Nimesulide, Meloxicam, HP-beta-cyclodextrin Binary Systems The purpose of the work is physicochemical characterization of nimesulide (NI) and meloxicam (ME}-hydroxypropyl-β-cyclodextrin (HP- β -CD) binary systems both in solution and solid states and to improve the pharmaceutical properties of NI and ME via inclusion complexation with HP- β -CD. Binary systems of NI and ME with HP- β -CD have been characterized both in solution and solid state by different physicochemical methods. Three types of drug-HP- β -CD binary systems. namely physical mixtures (PM), kneaded systems (KS) and co evaporated systems (CS) in 1:1 and 1:2 molar ratios (1:1 and 1:2 M) were prepared. Phase solubility and H-NMR spectroscopic studies in solution state revealed 1:1 M complexation of NI and ME with HP-p-CD. A partial inclusion of NI with HP- β -CD at both molar ratios of kneaded and co evaporated systems and a true inclusion of ME with HP- β-CD at both molar ratios of co evaporated systems in solid state was confirmed by differential scanning calorimetry (DSC), powder X-ray diffractometry (powder X-RD) and scanning electron microscopy (SEM) studies. Dissolution properties of NI and ME-HP- β -CD binary systems were superior when compared to corresponding pure drugs. The aqueous solubility and dissolution properties of NI and ME can be improved by inclusion complexation with HP- β -CD.