0 Tanaji Nandgude Rahul Thube Nitin Jaiswal Pradip Deshmukh Vivek Chatap Nitin Hire 2008 Int. J. of Pharm. Sci. and Nanotech 1 2 July-Sept. 2008 pH induced sol to gel conversion, Carbopol 934, HPMC, sustained release Nasal solutions of Salbutamol Sulphate were prepared for sustaining its release and improving its bioavailability. Carbopol was used as a key ingredient to effect pH induced sol to gel conversion of the formulations. Different formulations were prepared by varying the concentrations of Carbopol 934 and Hydroxyl Propyl Methyl Cellulose. These formulations were evaluated for parameters like pH, drug content, viscosity, gel strength and drug release. Release profile of some formulations showed rapid phase while some showed slow phase. At extreme low concentrations of the polymers, the formulations drained out due to poor viscosity while at higher concentrations of the same the formulations formed stiff gel and showed slow release of drug. Finally optimized formulation with specific concentrations of carbopol 934 and Hydroxyl Propyl Methyl Cellulose showed pH induced sol-gel conversion, sustained release and higher bioavailability. www.bspublications.net/downloads/04820432b2983c_IJPSN%20Journal%20brochuer.pdf