0 Ruckmani,K. Muneera,M.S. Vijaya,R. 2000 Boll. Chim.Farmac Anno 139(5) 1-4 ketorolac tromethamine,ketorolac formulation,sustained release formulations Matrix type formulations with dicalcium phosphate dihydrate (DCPD) using a polymeric binder (Eudragit RSPM) to obtain controlled release of Ketorolac tromethamine (KT) has been investigated. The drug, DCPD and Eudragit RSPM were granulated using isopropyl alcohol with and without a plasticizer (Diethyl phthalate, DEP). Addition of Eudragit appear to affect the release profile. However, addition of a plasticizer had a significant effect on the rate of release. The release appears to follow first order kinetics and the rate constant decreased linearly with increasing DEP concentration. A directly compressible mixture was also formulated by coating DCPD particles with DEP with and without Eudragit RSPM.