0 Saleem Shaikh*, M.S. Muneera , O.A Thusleem ,Muhammad Tahir, Anand V. Kondaguli and K.Ruckmani . 2007 Journal of Chromatographic science 45 6 311-314 July,2007 Rosiglitazone, online dissolution, poorly soluble drugs A new specific, accurate, precise and reproducible selective online dissolution method for rosiglitazone maleate has been developed and validated for the dissolution of rosiglitazone maleate in pharmaceutical formulations. The rationale of the method is based on the direct measurement of the absorbance of the analyte in the buffer medium, at 242 nm a using buffer as blank. Dissolution was achieved on a dissolution test apparatus consisting of photo diode array spectrophotometer (Agilent 8453), peristaltic pump and temperature controller (VK 750D), using 0.01N HCl and 0.05M potassium chloride as the dissolution medium. The proposed method was developed, optimized and validated in terms of linearity, reproducibility, accuracy and selectivity for the dissolution of rosiglitazone maleate in pharmaceutical formulations. The method was found to be linear in the range of 1 µg/mL to 14 µg/mL of rosiglitazoe maleate with a correlation coefficient of 0.999. The dissolution studies of rosiglitazone maleate tablets obtained by the proposed method were in good agreement with those by high-performance liquid chromatography.