0 Ved Parkash Yadav S. N. Pandeya U. K. Singh Vikash Kumar Amit Kukshal 2008 Synthesis & antimicrobial activity of 7-chloro-6-fluoro-N- [(1E)-(4-substituted phenyl) methylidene]-1,3-benzathiazole-2-amine INDIAN DRUGS 45(8) August 655-658 Benzothiazole, synthesis, antibacterial activity. 7-Chloro-6-fluoro-N-[(1E)-(4-substitutedphenyl) methylidene]-1, 3-benzothiazole -2-amine (4a-f) have been synthesized by the cyclization of 3-chloro-4-fluoroaniline (1) with potassium thiocyanate and bromine to give 7-chloro-6-fluoro-2-aminobenzothiaz ole (2) followed by treatment with aromatic aldehyde (3a-f) in presence of alcohol. The title compounds & their derivatives have been characterized by their spectral data. The synthesized compounds screened for their antibacterial activity against Gram negative and gram positive such as Escherichia coli MTCC 1687 & Staphylococcus aureus MTCC 737.