<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="6.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">P. V. Ingle</style></author><author><style face="normal" font="default" size="100%">R. D. Shimpi</style></author><author><style face="normal" font="default" size="100%">P. H. Patil</style></author><author><style face="normal" font="default" size="100%">V. G. Kuchake</style></author><author><style face="normal" font="default" size="100%">S. J. Surana</style></author><author><style face="normal" font="default" size="100%">P. N. Dighore</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">COMPARISON OF EFFECT OF METFORMIN IN COMBINATION WITH GLIMEPIRIDE AND GLIBENCLAMIDE ON GLYCAEMIC CONTROL IN PATIENT WITH TYPE 2 DIABETES MELLITUS</style></title><secondary-title><style face="normal" font="default" size="100%">International Journal of Pharmtech</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">Submitted</style></year></dates><abstract><style face="normal" font="default" size="100%">The aim of the present study was to compare the effect of metformin in combination with Glimepiride and Glibenclamide In patient with type 2 Diabetes Mellitus. Subjects and method: This is an open-label, randomized study carried out to study the effect of metformin when it is given in combination with either glimepiride or glibenclamide on glycaemic control in patient with type 2 Diabetes Mellitus. Patients with Glycosylated Hemoglobin more than 7% were included in the study. 31 patients were randomly assigned for treatment based on metformin-glibenclamide 1000/10 mg tablets or metformin-glimepiride1000/2mg for 12 weeks. The comparisons were conducted between these two groups for HbA1C, FPG, PPG and lipid profile. Result: At week 12, the significant reductions in HbA1c were found in both groups but the patients treated with metformin-glimepiride resulted in significantly greater reductions in HbA1C (-1.4%) than metformin-glibenclamide (-1.2%). Also the greater significant reductions were observed in case of FPG, total cholesterole, serum triglyceride and LDL cholesterole in patient with metformin-glimepiride group. Conclusion: Metformin-glimepiride tablets resulted in significantly greater reductions in HbA1C and fasting plasma glucose compared with metformin plus glibenclamide in patients with type 2 diabetes mellitus.</style></abstract></record></records></xml>