3 Suresh Kumar * Sandhya Bawa Sushma Drabu and B.P. Panda 2008 AICTE Sponsored National Seminar on Recent Advances in Pharmaceutical Sciences MSIP, Janakpuri, New Delhi 7-9/08/2008 antifungal activity, quinoline, A series of 2-chloro-3-(substituted phenyl/cyclohexyl/butylamino)methylquinolines (4a-n) was synthesized and tested for in-vitro antifungal activity against Aspergillus niger (MTCC, 281), Aspergillus flavus (MTCC,277), Monascus purpureus (MTCC,369) and Penicillium citrinum (NCIM, 768) and antibacterial activity against Escherichia coli (MTCCB, 1610), Staphylococcus aureus (MTCCB, 96) and Pseudomonas aeruginosa (MTCCB, 741) by serial plate dilutions method. Results of the preliminary screening revealed that some of the compounds mainly those with electron withdrawing groups in the phenyl ring showed promising antifungal activity. However these compounds were moderately active against bacterial strains.