Biodegradable polymers have been widely studied for several drug delivery systems for human health purpose. During the last two decades, advances in biodegradable materials have been made significantly for the development in biomedical applications, and in this category there are industrial applications as well.
Controlled and sustained drug delivery take place when a polymer (natural or synthetic) will prudently combined with a drug or other active substance in such a way that the active substance is released from the material in a tailored manner. The release of the active substance may be stable over a long period, it may be repeated over a long period, or it may be activated by the environment or other external actions. In any situation, the purpose behind controlling the drug delivery is to achieve more effective therapies while eliminating the adverse effects of both under- and overdosing.
The main advantages in using biodegradable polymers are there is no possibility of toxicity problems, their release rates can be customized and they degraded to form biocompatible or non-toxic products in biological fluids, which are removed from the body through normal metabolic pathways and physiological mechanisms. However, biodegradable polymers do produce ‘degradation by-products’ that must be tolerated with little or no adverse reactions within the biological environment.
For additional control and modulation of drug release using biodegradable polymers, Parenteral Depot Systems [PDS], Microspheres are also used.
Among the biodegradable polymers Poly-ε-caprolactone, Poly (lactide-co-glycolides) (PLGA) has been receiving increasing attention as matrix materials for controlled release drug formulations. Poly-ε-caprolactone and its derivatives, with a high permeability to many therapeutic drugs and lack of toxicity, are well suited for oral and controlled drug delivery.
In my power point presentation several biomaterials, mechanism of Biodegradation of Polymers, opportunities in controlled drug delivery in future e.t.c. in discussed in detail.