Research and Development jobs

The Genetics division resides within Drug Discovery and applies human genetics expertise to projects in all phases of the GSK pipeline. The division supports GSK strategy by providing deep scientific insight to improve target validation and the efficacy/safety of innovative new medicines.

The successful candidate will join a Product Development Team within the Biopharmaceutical Technologies department of The Biopharm R&D Unit, and will work on developing drug product and delivery systems for protein & peptide-based therapeutics.

Responsible for whole cell electrophysiology patch-clamp experiments on various cardiac ion channels in both planar chip and standard whole cell patch clamp. In depth understanding of the biophysics of channel activation and inactivation and the onset/offset kinetics of block, for all major cardiac ion channels.

We are passionately committed to discovering and delivering the next generation of innovative therapies to help cancer patients live longer, happier and healthier lives.

- Assure timely development of CMC development of biopharm projects which enable successful preparation of preclinical and clinical supplies to appropriate standards
- Overall accountability of ensuring that CMC development of early phase biopharm portfolio is optimal

edical degree, ideally with post-graduate qualification and experience of working in academia in a clinical or scientific setting. At least three years experience in Industry, ideally in Discovery Medicine
A background of establishing and maintaining excellent and functional working relationships with collaborators both within and outside GSK

• Leads the development, management, and implementation of reimbursement and access strategies (R&A), as well as Global Health Outcomes (GHO) strategies and deliverables to include health economics and patient reported outcome measures (PROs) within one or more TAs to support the regulatory and commercial objectives of GSK's products during discovery, development, launch, and life cycle managemen

The successful applicant will have the following responsibilities:
a)identification and validation of targets suitable for biopharmaceutical intervention
b)manage a matrix organization in all phases of biology required to bring a molecule from early validation through to clinical candidacy

GlaxoSmithKline is seeking a Senior Scientist for its Research Triangle Park location to conceive and plan efficient synthetic routes to molecules of interest; design laboratory experiments, conduct synthetic reactions toward target molecules, and develop synthetic methods as needed within the HIV Drug Discovery organization; utilize appropriate state-of-the-art techniques for isolating and charac

Identify and characterize fit-for-purpose mammalian cellular systems and assay readouts; develop high quality cell-based assays for high throughput screening, compound profiling, and mode of action studies in connection with candidate molecule progression, and participate in the implementation of the assays; conduct experiments directed towards determination of antagonist/agonist mechanisms; evalu