Target delivery of drug molecules to brain is one of the most challenging research areas in pharmaceutical sciences. The blood-brain barrier (BBB) represents an insurmountable obstacle for a large number of drugs, including antibiotics, antineoplastic agents, and a variety of central nervous system (CNS)-active drugs, especiallyneuropeptides. Therefore, various strategies have been proposed to improve the delivery of different drugs to this tissue which includesliposomes, colloidal drug carriers, micelles, chimeric peptide technology, intranasal and olfactory route of administration andnano technology.
The BBB is located at the level of brain capillaries, where there is a convergence of different cell types. The brain micro vessel endothelial cell (BMEC) that form the BBB, display important morphological characteristics such as the presence of tight junctions between the cells, the absence of fenestrations and a diminished pinocytics activity, that together help to restrict the passage of compounds from the blood into the extra cellular environment of the brain
The present topic deals in brief about the status of the BBB. The first part of this topic aims to review the strategies developed to circumvent the BBB and deliver drugs into the brain. The use of nano technology and liposomes are discussed which are crucial parts of this power point presentation as mainly used to target various CNS disorders. The later part contains future aspects of brain drug targeting...
Our power point presentation deals with Brain targeting technology, Colloidal drug carriers, Micelles, Liposomes, nano Technology