Audio topic - polymers in drug delivery

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A Polymer consists of repeated subunits of monomers which may or may not be similar in structure1

They may be attached linearly or branched
High molecular weight compounds1

Polymers act as drugs (eg: Insulin and Heparin which are proteins consists of monomers of amino acids)

Gelatin is also a polymer that is used in manufacture of capsule shells, as tablet binder, suppository base2

Acacia is a carbohydrate polymer that is used as tablet binder2


Crospovidone is a polymer acting as disintegrant2

PEG is also a polymer that acts as ointment base2

Sodium CMC is the polymer that that acts as emulsifying and suspending agents2


Polymers are also used as gelling agents (eg: Carbomer 940)2

Polymers can be used as ion exchange resins – styrene/divinylbenzene copolymers3

Polymers can be used for enteric coating, film coating, sustained release coating
Enteric coating – cellulose acetate phthalate, film coating- Hydroxypropyl methyl cellulose, Sustained release coating- Ethyl cellulose2

Depending on mechanism of drug release polymers can be classified as, polymers that form erodible matrix-carnuba wax, hydrophilic matrix – Hydroxy ethyl cellulose, Insoluble matrix- Polyethylene, pH dependent polymers- Eudragit L 100

Polymers for formulation of nanoparticles- PLA (Poly Lactic acid), PLGA Poly ( lactic co-glycolic acid) which are biodegradable4

Polymers as closures (rubber), syringes (polypropylene)5,

Blister and strip packing materials (Polyester)5

Polymers have wide applications in pharmacy starting from acting as drugs, formulation adjuants and packaging materials

 

References:

1.        http://www.wisegeek.com/what-are-polymers.htm

 2.           Raymond C Rowe, Paul J Sheskey,
Marian E Quinn Hand Book of  Pharmaceutical      
           excipients 
6th edition, Pharmaceutical Press and American Pharmaceutical association 2009.   
 3.           http://fabad.org/fabad.org/pdf/volum32/issue2/91-100.pdf

4.         T. Musumeci et. al. PLA/PLGA nanoparticles for sustained release of docetaxel

       International Journal of Pharmaceutics, Vol. 325,
Issues 1-2
, Pages 172-179, 15                        November 2006.

5.         http://www.sepha.com/en/downloads/blisterpackaging-materials

 

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