DYING FOR IRON...
Food supplements, such as the blue-green alga popularly referred to as spirulina, are used worldwide and can serve as valuable sources of vitamins and minerals. Iron is one of the many elements that are needed for life yet are toxic in excess. In the small intestine—particularly in the first 12–finger-width segment known as the duodenum—epithelial cells express the iron-regulatory proteins (IRP1 and IRP2) that maintain iron homeostasis by adjusting the expression of proteins that absorb, metabolize, and export this essential dietary component. By selectively eliminating the expression of IRPs in these cells in mice, Galy et al. demonstrate that they are also required for intestinal development. They observed that mice deficient in IRPs suffered from weight loss and dehydration and died a few weeks after birth. Surprisingly, the mice manifested close to normal blood and liver iron content; on the other hand, intestinal villi were malformed, and duodenal epithelia displayed degenerated mitochondria (perhaps a sign of diminished iron-sulfur cluster synthesis) and increased cell death, which probably contributed to impaired water and nutrient absorption. Thus, although the absence of IRPs in the intestinal epithelium does not acutely alter systemic iron levels, it does affect intracellular processes that control intestinal morphogenesis and survival.
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annapurna u
Thu, 04/02/2009 - 12:44
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Keep going!!!
Great you outlined the importance of iron in the body...Both pros and cons are explained well...Thank you so much and i wish u a very all the best..
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sirisha
Fri, 04/03/2009 - 15:46
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Thank you annapurna and
Thank you annapurna and ragha naveen,,,,your comments are valuable..
zarrinfaria
Thu, 04/02/2009 - 14:19
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Good job.... What is the
Good job....
What is the major indication for using spirulina is it used as the food supplement????
What is the source of your information........
Can you provide some more information on spirulina???
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sailajabyrisetty
Thu, 04/02/2009 - 14:26
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Good Questions
I got the same questions after reading ...Seems like link is missing in presenting information...
sirisha
Fri, 04/03/2009 - 15:59
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hope your questions are
hope your questions are properly handled by me sailaja...if not please put forth your queries...
sirisha
Fri, 04/03/2009 - 15:58
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Thank you faria for your
Thank you faria for your valuable comment....
Spirulina is the common name for human and animal food supplements similar to Chlorella and Aphanizomenon flos-aquae (Blue Green Algae.) Spirulina comes from two different species of cyanobacteria: Arthrospira platensis, and Arthrospira maxima. These are free-floating filamentous cyanobacteria characterized by cylindrical, multicellular trichomes in an open left-hand helix. Spirulina occurs naturally in tropical and subtropical lakes with high pH and high concentrations of carbonate and bicarbonate.
Faria..spirulina has got many nutritional values as it contains highest amount of proteins (55-77%). It is a complete protein containing essential amino acids like methionine, cysteine and lysine. It is rich in Vit B1,B2,B6,B3,B9, C,D,E.
Finally,,,i got the info from the site www.sciencemag.org
kranthikumar
Thu, 04/02/2009 - 14:38
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Iron,,,
Dear Sirisha,
In your blog initally you have mentioned that IRPs are important for the iron absorbing but finally you mentioned that absence willl not affect the iron level. Is it not controducting to each other, Can you give me the reference or explain the mechanism.
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sirisha
Fri, 04/03/2009 - 16:23
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Dear kranthi,, Thank you for
Dear kranthi,,
Thank you for your valuable comment..
As you know, iron is an important element in the body. Deficiency or overload of iron may lead to diseases or disorders in the body,
The iron regulating protein, called IRP1, has two structural forms, each with important functions within the cell.
When serving as one of two regulators of cellular iron metabolism through its control of gene expression, the tightly coiled IRP1 opens up to expose sites that bind messenger RNA at sites on the RNA called iron responsive elements, or IREs, that are common in genes involved in iron metabolism.
In its alternate form, IRP1 binds a cluster of iron and sulfur atoms to act as an important metabolic enzyme called aconitase. The assembly and disassembly of the iron/sulfur cluster in the aconitase form appears to be an effective mechanism for regulating IRP1 activity.
Still clinical trials are going on mammalian tissues.
These IRP's are involved in maintaining the homeostasis of iron content in the body. Galy et al conducted experiments in the body showed that the mice deficient of iron content and mice having normal iron content and nutrition in the body showed the same results. Hence he proposed that either the deficiency or normal levels does not affect the intracellular process.
kranthikumar
Mon, 04/06/2009 - 15:53
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Himmm, ok
Dear sirisha,
what about the referance.
Regards
Kranthi
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sirisha
Thu, 04/09/2009 - 02:39
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Dear kranthi...i got this
Dear kranthi...
i got this matter from www.sciencemag.org
raghanaveen
Thu, 04/09/2009 - 08:56
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well sirisha,
well sirisha,
Your explanation about importance of iron to the human’s and the function of iron-regulatory proteins i.e. IRP1 and IRP2 was nice.
You said that for better iron supplement you preferred blue-green alga i.e. Spirulina, but it has some disadvantages like severe contamination during growth, having high amount of chlorophyll which is not suitable for human consumption and also has low dry weight.
So why should you preferred this blue-green alga for iron supplement and why not
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juhis
Sat, 04/04/2009 - 05:42
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nice
after reading ur blog we hav come to know more abt the imp. of spirulina.
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vbsishwarya
Sat, 12/05/2009 - 01:13
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good info
good info