KELOIDS..
What is a keloid and how do you get one??
Keloid is a scar that does not know when to stop forming, becoming, large, shiny, smooth and often pink and dome shaped according to The Merck Manual of Diagnosis and Therapy. It is not known why some people get overgrown scars after injuries, surgery, acne but keloids are more common among people of black and Asian descent, so a genetic factor is suspected.
In normal scarring, after the inflammation that follows an injury subsides, scar tissue begins to form, along with tiny new blood vessels.
Cells in the skin around the injury, called fibroblasts, produce collagen, a fibrous connective tissue. As more and more of the fibers link up, the scar becomes harder. In a keloid, the process continues long after the wound is covered over, and the scar becomes quite large.
Keloids are not dangerous but can be disfiguring, tender and sometimes itchy. Removal of a keloid by surgeryor the use of lasers, followed by corticosteroid injections at the site, is sometimes but not always successful and can cause even worse scarring.
Someone with a tendency to form keloids may want to avoid plastic surgery, though doctors can sometimes use hidden incisions in facial surgery or avoid making cuts in the periphery of the face, where keloids are more likely to form.
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sirisha
Fri, 04/24/2009 - 16:24
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Hi all this is a very
Hi all
this is a very general topic...where i found in a book...i didnt have much idea about keloids..until i collected this matter.
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kranthikumar
Fri, 04/24/2009 - 17:08
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Good information, Can you mention Referance,
Dear Sirisha,
Good information, YOu have mentioned "Cells in the skin around the injury, called fibroblasts, produce collagen, a fibrous connective tissue. As more and more of the fibers link up, the scar becomes harder." this is good can you try to give some more information like what is the mechanism behind it??
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Kranthi
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zarrinfaria
Sat, 04/25/2009 - 14:08
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Absolutely amazing never
Absolutely amazing never heard of before...Is there any research being carried out in this feild to find out the cause of occurence...
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Faria Zarrin
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sirisha
Sat, 04/25/2009 - 15:19
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dear faria and
dear faria and kranthi,,,,
Here is the occurance and more detailed info regarding keloids..
Keloids expand in claw-like growths over normal skin. They have the capability to hurt with a needle-like pain or to itch without warning, although the degree of sensation varies from patient to patient.
If the keloid becomes infected, it may ulcerate. The only treatment is to remove the scar completely. However, the probability that the resulting surgery scar will also become a keloid is high, usually greater than 50%.
Keloids form within scar tissue. Collagen, used in wound repair, tends to overgrow in this area, sometimes producing a lump many times larger than that of the original scar. Although they usually occur at the site of an injury, keloids can also arise spontaneously. They can occur at the site of a piercing and even from something as simple as a pimple or scratch. They can occur as a result of severe acne or chickenpox scarring, infection at a wound site, repeated trauma to an area, excessive skin tension during wound closure or a foreign body in a wound. Keloids can sometimes be sensitive to chlorine.
Biologically, keloids are fibrotic tumors characterized by a collection of atypical fibroblasts with excessive deposition of extracellular matrix components, especially collagen, fibronectin, elastin, and proteoglycans. Generally, keloids contain relatively acellular centers and thick, abundant collagen bundles that form nodules in the deep dermal portion of the lesion. Keloids present a therapeutic challenge that must be addressed, as these lesions can cause significant pain, pruritus (itching), and physical disfigurement. They may not improve in appearance over time and can limit mobility if located over a joint.
Keloids affect both sexes equally, although the incidence in young female patients has been reported to be higher than in young males, probably reflecting the greater frequency of earlobe piercing among women. There is a fifteen times higher frequency of occurrence in highly pigmented people. It is speculated that people who possess any degree of African descent, regardless of skin color, may be especially susceptible to keloid occurrences
Sirisha Pingali
http://www.pharmainfo.net/sirisha
Viswanadha Institute of Pharmaceutical Sciences.
www.vnips.edu.in