PRECAUTION AGAINST LEUKOTRIENE INHIBITORS..
(9 votes)
Recently FDA has recommended precaution against drugs Montelukast (marketed as Singulair), Zafirlukast (marketed as Accolate), and Zileuton (marketed as Zyflo and Zyflo CR). These drugs are used as leukotriene inhibitors and has led to neuropsychiatric events which include post market cases of aggression, agitation,dream abnormalities,hallucinations,depression,insomnia,irritation etc. So FDA recommended the following precaution in drug labelling..
*Patients and healthcare professionals should be aware of the potential or neuropsychiatric events with these medications.
*Patients should talk with their healthcare providers if these events occur.
*Healthcare professionals should consider discontinuing these medications if patients develop neuropsychiatric symptoms.
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Dear Sirisha
They are used for Asthma patients showing promising effects,
So, why cant it be used in asthma patients despite its systemic side effects...
Regards,
Santosh Kumar
dear santosh..Why do people
dear santosh..
thank you for your valuable comment..
Infact this is good question posted by you..
Please click on the following link to know about leukotrienes in asthma treatment..
http://www.aafp.org/afp/20070101/65.html
Sirisha Pingali http://www.pharmainfo.net/sirisha/biography
nice blog
nice blog
Supriya vavilapalli
THE COGNITIVE MOLECULES
http://www.pharmainfo.net/supriya-vavilapalli
dear supriya.. thank you for
dear supriya..
thank you for your valuable comment..
Sirisha Pingali http://www.pharmainfo.net/sirisha/biography
Good Information
Dear Sirisha,
Very great of you that you provided the latest and updated information about the drugs used in market.You are absolutely correct but these leukotriene inhibitors when given with some CNS stimulants was found to have decreased the symptoms you have mentioned.This is as far as my knowlede.please correct me if I am wrong.
http://www.pharmainfo.net/ks-kumar-upadhyayula
dear suresh.. Thank you for
dear suresh..
Thank you for your valuable comment..
See i collected the drug interactions of the individual drugs...So everywhere you can see the main interacting drug is ASPIRIN..
Drugs that may interact with montelukast include:
aspirin
NSAIDs
phenobarbital
rifampin
Medications that may interact with zafirlukast include:
aspirin
blood pressure medications
some seizure medications
Medications that may interact with zileuton include:
the beta-blocker propanolol
beta-agonists
terfenadine (Seldane and others)
Sirisha Pingali http://www.pharmainfo.net/sirisha/biography
Nice Information
Dear Sirisha,
Very elaborately provided the information and very detailed answer.Nice on your part.
http://www.pharmainfo.net/ks-kumar-upadhyayula
thank you suresh..keep
thank you suresh..keep posting your comments..
Sirisha Pingali http://www.pharmainfo.net/sirisha/biography
Is it all ?
Dear Sirisha,
Good infomration But is it all the precautions to be taken ?
Is there not any alternative drugs for it ?
Is it harmful to any body tissue ?
Regards Kranthi http://www.pharmainfo.net/kranthikumar/biography
dear kranthi.. Thank you for
dear kranthi..
Thank you for your valuable comment..
See..previously leukotriene antagonists are used to treat asthma,rhinitis etc. FDA had recently introduced leukotriene modifiers instead of leukotriene antagonists(of course both are dealt under same heading leukotriene inhibitors). In other words these are alternative medications available.
For eg.Montelukast is recommended as an alternative medication to inhaled corticosteroids or as adjunctive therapy for the treatment of mild and moderate persistent asthma. These do not affect a particular body tissue. Common side effects seen is headache accounts for 18% individuals.
Sirisha Pingali http://www.pharmainfo.net/sirisha/biography
Ma'am can you explain in
Ma'am can you explain in brief about leukotriene inhibitors?
Naman Team Infinity
"∞"
http://www.pharmainfo.net/blog/team-infinity
dear naman thank you for your
dear naman
thank you for your valuable comment..
As you know there is lot to cover under Leukotriene inhibitors. In short,Leukotriene inhibitors are prescription medications that treat asthma and some allergies by blocking the formation or activity of leukotrienes—small mediator chemicals produced by cells in the body.
Sirisha Pingali http://www.pharmainfo.net/sirisha/biography
Dear Srisha, Good
Dear Srisha,
Good information...what were the grounds on which such declerations were made any studies....
Regards,
Faria Zarrin
Team: BLOGBUSTERS
My Page :
http://www.pharmainfo.net/zarrinfaria/biography
My Team:
http://www.pharmainfo.net/blog/blogbusters
dear faria.. thank you for
dear faria..
thank you for your valuable comment..
This declaration is made by some Pulmonary healthcare professionals..Here is the original link where i collected my matter.
http://www.drugs.com/fda/leukotriene-inhibitors-montelukast-marketed-sin...
Please do reply if you are not satisfied.
Sirisha Pingali http://www.pharmainfo.net/sirisha/biography
Dear Sirisha, Thank you for
Dear Sirisha,
Thank you for providing such alerting information.
what kind of Dream abnormalities does it lead to?
Regards
Aishwarya
Aishwarya
http://www.pharmainfo.net/vbsishwarya/biography
BLOGGING BEES
dear aishwarya thank you for
dear aishwarya
thank you for your valuable comment..
Dream abnormalities are one of the neuropsychiatric symptoms seen in this. Emotional liability, nervousness may be seen.
Sirisha Pingali http://www.pharmainfo.net/sirisha/biography