KRIMSON 35-THE DRUG MOSTLY USED TO TREAT PCOD

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CYPROTERONE ACETATE AND ETHINYLOESTRDIOL TABLETS:

compositon:
Each film coated tablet contains:
cyproterone acetate BP 2mg
ethinyloestradiol IP 0.035mg

CLINICAL PHARMACOLOGY:
it combines with cyproterone acetate ,a potent antiandrogen and ethinyl oestradiol,a semisynthetic derivetive of oestradiol.

MECHANISM OF ACTION;
The function of sebaceous glands is mostly dependent on androgens.Androgens stimulate the mitotic activity in the sebaceous glands ,fibroblasts and hair follicles.seborrhea,the increased production of sebum ,plays an important role in the genesis of acne.
cytoproterone acetate contained in krimson-35 blocks androgen receptors.it also reduces androgen synthesis both by negative feedback effect on the hypothalamo pituitary ovarian system and by the inhibition of androgen synthesizing enzymes.
The stimulating effect of male sex hormones on androgen dependant structures and functions is weakened or abolished by cytoproterone acetate.
It inhibits the influence of androgens and reduces the activity of sebaceous gland.apart from this, it also has a progestational action.
Ethinyloestrdiol in the combination inhibits ovulation and changes the cervical mucus and the endomerium rendering them unfavourable for sperm penetration and nidation of a fertilized ovum respectively........

Although it acts as a oral contraceptive,it is not recommended in women solely for contraception.

CONTRAINDICATIONS;
.pregnancy or lactation
.sickle cell anaemia
.venous and arterial thrombotic or embotic process
.herpes gestations
.severe diabetes mellitus
.liver disturbances,jaundice etc

SIDE EFFECTS:
.HEADACHE,NAUSEA,GASTRIC UPSETS,VOMITING,BREAST TENDERNESS,DEPRESSIVE MOODS,CHANGES IN LIBIBO.
.CHLOASMA(EXCERBATED ON EXPOSURE TO SUNLIGHT)

DOSAGE AND ADMINISTRATION:
It is available in blister strips of 21 tablets.each tablet marked with the day of the week
One tab daily for 21 days.therapy should start on day 1 of the cycle91st day of menstural cycle is taken as 1)it can be taken at any time ,but the timing should be followed that is continued.taken until the strip is completed .

MANUFACTURER:
SUN PHARMACEUTICALS
MUMBAI

REFERENCE:
www.sunpharma.com

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Comments

Badrud's picture

Informative blog.

SUPRIYA VAVILAPALLI's picture

thank u sir

Sirisha Pingali's picture

dear supriya..
Very good collection regarding Krimson 35..I got to know few interestig facts regarding this.

Sirisha Pingali

http://www.pharmainfo.net/sirisha

Viswanadha Institute of Pharmaceutical Sciences.

www.vnips.edu.in

SUPRIYA VAVILAPALLI's picture

thank u

Anonymous's picture

Hie Supriya,

 

At the onset thank you for the article on Krimpson 35.

 

I am currently taking this tablet for my PCOD thngy. is it safe to continue these medicines after reading the side effects. I feel i get headaches quite often and at times pain in ma chest.

 

Kindly advise..

Merci

yash...