In-vitro antifungal activity of newly synthesized 2-chloro-3-(substituted phenyl/cyclohexyl/butylamino) methylquinolines.

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Submitted by sureshkr_pharm on Sun, 10/12/2008 - 19:46
TitleIn-vitro antifungal activity of newly synthesized 2-chloro-3-(substituted phenyl/cyclohexyl/butylamino) methylquinolines.
Publication TypeConference Paper
Year of Publication2008
Authors*, S K, Bawa S, Drabu S, Panda BP
Conference NameAICTE Sponsored National Seminar on Recent Advances in Pharmaceutical Sciences
Conference Start Date7-9/08/2008
Conference LocationMSIP, Janakpuri, New Delhi
Keywordsantifungal activity quinoline
Abstract

A series of 2-chloro-3-(substituted phenyl/cyclohexyl/butylamino)methylquinolines (4a-n) was synthesized and tested for in-vitro antifungal activity against Aspergillus niger (MTCC, 281), Aspergillus flavus (MTCC,277), Monascus purpureus (MTCC,369) and Penicillium citrinum (NCIM, 768) and antibacterial activity against Escherichia coli (MTCCB, 1610), Staphylococcus aureus (MTCCB, 96) and Pseudomonas aeruginosa (MTCCB, 741) by serial plate dilutions method. Results of the preliminary screening revealed that some of the compounds mainly those with electron withdrawing groups in the phenyl ring showed promising antifungal activity. However these compounds were moderately active against bacterial strains.