Tablet Chipping Causes and Remedies

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Tablet Chipping Causes and Remedies

1.10.1.3 Chipping (1)

Definition: 'Chipping' is defined as the breaking of tablet edges, while the tablet leaves the press or during subsequent handling and coating operations.

Reason: Incorrect machine settings, specially mis-set ejection take-off.

Table.31. The Causes And Remedies Of Chipping Related To Formulation (Granulation) Are As Follows

Sr. No.

CAUSES

REMEDIES

1.

Sticking on punch faces

Dry the granules properly or increase lubrication.

2.

Too dry granules.

Moisten the granules to plasticize. Add hygroscopic substances.

3.

Too much binding causes chipping at bottom.

Optimize binding, or use dry binders.

Table.32. The Causes And Remedies Of Chipping Related To Machine (Dies, Punches And Tablet Press)

Sr. No.

CAUSES

REMEDIES

1.

Groove of die worn at compression point.

Polish to open end, reverse or replace the die.

2.

Barreled die (center of the die wider than ends)

Polish the die to make it cylindrical

3.

Edge of punch face turned inside/inward.

Polish the punch edges

4.

Concavity too deep to compress properly.

Reduce concavity of punch faces. Use flat punches.

About the Author

Dr.Mukesh Gohel's picture
Author: Dr.Mukesh Gohel

Dr. Mukesh Gohel is principal, professor at the LMCP, Ahmedabad served in academics for more than 40 years. He provides training in leading pharmaceutical industries in the areas of Design of Experiments and Quality by Design. His current areas of interest are direct compression and improvement of drug dissolution.

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