Tablet Lamination Causes and Remedies

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Tablet Lamination Causes and Remedies

1.10.1.2 Lamination / Laminating (1,5)

Definition: 'Lamination' is the separation of a tablet into two or more distinct horizontal layers.

Reason: Air-entrapment during compression and subsequent release on ejection.

The condition is exaggerated by higher speed of turret.

Table.29. The Causes And Remedies Of Lamination Related To Formulation (Granulation)

Sr. No.

CAUSES

REMEDIES

1.

Oily or waxy materials in granules

Modify mixing process. Add adsorbent or absorbent.

2.

Too much of hydrophobic lubricant e.g.: Magnesium-stearate.

Use a less amount of lubricant or change the type of lubricant.

Table.30. The Causes And Remedies Of Lamination Related To Machine (Dies, Punches And Tablet Press)

Sr. No.

CAUSES

REMEDIES

1.

Rapid relaxation of the peripheral regions of a tablet, on ejection from a die.

Use tapered dies, i.e. upper part of the die bore has an outward taper of 3deg to 5deg.

2.

Rapid decompression

Use pre-compression step. Reduce turret speed and reduce the final compression pressure.

About the Author

Dr.Mukesh Gohel's picture
Author: Dr.Mukesh Gohel

Dr. Mukesh Gohel is principal, professor at the LMCP, Ahmedabad served in academics for more than 40 years. He provides training in leading pharmaceutical industries in the areas of Design of Experiments and Quality by Design. His current areas of interest are direct compression and improvement of drug dissolution.

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