Pharmaceutical Tablet Sticking / Filming

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Tablet Sticking

1.10.1.5

Tablet Sticking / Filming Problem and Solutions

(1)

Definition: 'Sticking' refers to the tablet material adhering to the die wall.

Filming is a slow form of sticking and is largely due to excess moisture in the granulation.

Reason: Improperly dried or improperly lubricated granules.

Table.35. The Causes And Remedies Of Sticking Related To Formulation (Granulation)

Sr. No.

CAUSES

REMEDIES

1.

Granules not dried properly.

Dry the granules properly. Make moisture analysis to determine limits.

2.

Too little or improper lubrication.

Increase or change lubricant.

3.

Too much binder

Reduce the amount of binder or use a different type of binder.

4.

Hygroscopic granular material.

Modify granulation and compress under controlled humidity.

5.

Oily or way materials

Modify mixing process. Add an absorbent.

6.

Too soft or weak granules.

Optimize the amount of binder and granulation technique.

Table.36. The Causes And Remedies Of Sticking Related To Machine (Dies, Punches And Tablet Press)

Sr. No.

CAUSES

REMEDIES

1.

Concavity too deep for granulation.

Reduce concavity to optimum.

2.

Too little pressure.

Increase pressure.

3.

Compressing too fast.

Reduce speed.

About the Author

Dr.Mukesh Gohel's picture
Author: Dr.Mukesh Gohel

Dr. Mukesh Gohel is principal, professor at the LMCP, Ahmedabad served in academics for more than 40 years. He provides training in leading pharmaceutical industries in the areas of Design of Experiments and Quality by Design. His current areas of interest are direct compression and improvement of drug dissolution.

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