Comparative study of tannate salt and hydrochloride salt of Diphenhydramine

tanajinandgude's picture
Submitted by Tanaji Dilip Na... on Fri, 05/16/2008 - 05:51.

Publication Type:

Poster Presentaion

Authors:

Nandgude Tanaji; Bhise Kiran

Source:

Second International Conference and Indo – Canadian Satellite Symposium on Pharmaceutical Sciences, Technology, Practice and Natural Health Products, J.S.S. College of Pharmacy, Ooty (TamilNadu) (2007)

Abstract:

The objective of the work was to perform the characterization study of Tannate and Hydrochloride salt of Diphenhydramine (DPH) and there formulations. DSC, XRPD, FTIR, SEM and solubility studies were carried out. DSC and XPRD studies indicated amorphous nature of the Tannate salt and crystalline nature of HCl salt. With help of SEM surface characteristics of both salts were differentiated. pH dependent solubility of both the drugs was observed indicating HCL salt is more soluble than Tannate. Tannate salt was evaluated for oral sustained release tablet of DPH in comparison with DPH HCL conventional and SR tablet. SR tablet of DPH HCl was prepared using HPMC K4M. In-vitro drug release studies were conducted at pH 6.8 and pH 1.2 buffers. Release studies demonstrated pH dependent sustained release of drug from DPH Tannate and DPH HCl SR tablets. Drug release decreased as polymer: drug ratio increased from 1:1 to 1:4.