Technical Articles

B.Dhandapani

A. Suganthi, P. Ravimathi*, Sapna Shrikumar, and T.K. Ravi.

College of Pharmacy, Sri Ramakrishna Institute of Paramedical Sciences, Coimbatore
– 44.

P. Ravimathi

A simple, fast, specific and precise High Performance Thin Layer Chromatographic
Method (HPTLC) has been developed for estimation of Aripiprazole in tablet dosage
form.

The stationary phase silica gel G60F₂₅₄ was selected for separation
and the sample was developed using a mixture of ethyl acetate: methanol in the
ratio 10.5: 0.5 v/v as mobile phase. Quantification was carried out at 260 nm
photometrically. The R_f value of Aripiprazole was found to be 0.25
± 0.02. Linearity was found to be in the concentration range of 200 to 1000

Kshirsagar S. J

Tinidazole was microencapsulated within various cellulose polymers like Ethyl
cellulose, Eudragit – L & Cellulose Acetate Phthalate (CAP) with the final
aim to mask its taste without affecting its bioavailability.

The Microspheres were prepared using the solvent evaporation technique. The
contribution of different variables like polymer type, drug polymer ratio, stirring
speed, polymer solution concentration, surfactant concentration and type of
the surfactant on microencapsulation of Tinidazole were examined. Reconstitutable
suspension of microencapsulated Tinidazole was formulated comprising of 1:2
drug polymer ratio.

The results demonstrated that the use of CAP as embedding polymer gave good

Principle of the experiment:

The technique used to separate an organic compound from a mixture of compounds is called Extraction. Extraction process selectively dissolves one or more of the mixture compounds into an appropriate solvent. The solution of these dissolved compounds is referred as the Extract. Caffeine is a naturally occurring alkaloid (a class of naturally occurring compounds containing nitrogen and having the properties of an organic amine base) found in coffee, tea, Cocoa, Guarana (Paullinia cupana)  and kola nuts.  

in the treatment of metastatic apocrine carcinoma: a case report and review of the literature

Abstract

We report a case of metastatic apocrine carcinoma arising from the peri-anal region. Partial response was achieved after a course of the combination chemotherapy with evidence of clinical, biochemical and radiological improvement. There are seldom reports available on the treatment of the primary or advanced disease, in particular the role of chemotherapy is not well defined.

Case report

Mousumi Kar* and Dr P K Choudhury**

*&**Dept. of Pharmaceutical Sciences, MLSU, Udaipur *Corresponding
author & email: mousumi_s@rediffmail.com

In the present study, an effort has been made to develop chitosan microspheres for a water-soluble antidiabetic drug. The microspheres were prepared by denaturation process to retard the drug release and to obtain maximum drug loading. The prepared microspheres were characterized by loading efficiency, % entrapment, optical microscopy, scanning electron microscopy and release characteristics. The morphology of the microspheres was well within permissible limits, with size in the range of 200 to 250m. The drug release was sustained for more than 8 hrs. The drug release followed higuchi kinetics, indicating diffusion controlled drug release.

A. Goyal * and I. Singhvi **  

^* B. N. P.G. College of Pharmacy, Udaipur (Raj.) 313002

** Department of Pharmaceutical Sciences, M. L. Sukhadia University, Udaipur
(Raj.) 313001

* For correspondence :Mailing Address: 277,Sector
11, Hiran Magari, Udaipur(Raj.), 313001.Telephone No. : 02942584851, Mobile:
09828135201,e-mail-goyalanjugoyal@yahoo.com

Abstract:

Two simple, economical, precise, convenient and reproducible visible
spectrophotometric methods have been developed for the estimation of repaglinide
in tablet formulation. The developed methods are based on the formation of chloroform
extractable complex of repaglinide with chlorophenol red and bromophenol blue

The present study was under taken to analyze the data of serum concentration
of four commonly used antiepileptic drugs in referred patients with an idea
to assess its utility to the physician in the management of patients with epilepsy.
A total of 95patients, of both genders and aged between 7-50 years, were analyzed.
Plasma levels of the drugs were measured by homogeneous enzyme immunoassay using
semiautomatic analyzer (Erba Chem Pro).The results of the present study establishes
the relationship between drug concentration and biological effects. In the present
study 20% of all the patients (60% on phenytoin and 25% on phenobarbitone) had
sub-therapeutic levels. These patients required dosage increments for
better control of seizures. Majority of the patients (50%) had serum levels

A. Goyal * and I. Singhvi **

*  B. N. P.G. College of Pharmacy, Udaipur (Raj.) 313002

** Department of Pharmaceutical Sciences,  M. L. Sukhadia University,
Udaipur (Raj.) 313001

* For Correspondence

Mailing address: 277,Sector 11, Hiran Magri, Udaipur(Raj.),313001.Telephone
No.: 02942584851, mobile: 09828135201.

E-mail-goyalanjugoyal@yahoo.com

Abstract:

Three simple, economical, precise, convenient and reproducible visible spectrophotometric
methods have been developed for the estimation of risperidone in tablet formulation.
The developed methods are based on the formation of chloroform extractable complex
of risperidone with bromophenol blue, bromothymol blue and bromocresol green
in acidic medium, which shows absorbance maxima at 412.0 nm, 413.0 nm and 414.0

A Quantitative Structure Activity Relationship (QSAR) study of the 2,3-diaryl cyclopentenones was made using APEX 3-D INSIGHT II Software. The various biophoric and secondary sites were identified and used for deriving QSAR equations. Several statistical regression expressions were obtained during multiple linear regression analysis. The best QSAR model was further validated by Leave One Out cross validation method. The parameters like refractivity, hydrophobicity, hydrogen bonding site etc were found to be significant.

Key words : 3D-QSAR, Diaryl Cyclopentenones, Selective Cyclooxygenase –2 Inhibiters