Dosage forms

Similarities between Wet granulation and Ruti cooking

Submitted by Mumita Meshkat on Wed, 11/14/2012 - 07:28

Actually, Pharmaceuticals processing and production have similarities to cook something. Some examples of that are, processing similarities between wet granulation and Ruti or Chapati cooking. Another example of this kind similarities are emulsion production with curry cooking. Though pharmaceuticals processing is similar to cooking but pharmaceuticals processing is done in the more precise, more controlled and more systemic ways to provide stability for prolong period.

Enhancement of dissolution using multiparticulates

Submitted by sailesh on Sun, 05/29/2011 - 11:28

About 40% of the drug compounds are poorly water soluble1. This poor water solubility results in decreased rate and extent of dissolution and hence bioavailability. The formulation of a dosage form for these compounds is a challenging aspect. A number of techniques like micronization, nanonization, salt formation, complexation, solid dispersions, and use of different polymorphic form of the drug are being tried to improve the water solubility of drug compound. Each technique has its own limitations.

topics for the month may

Submitted by satheeshbabu on Fri, 05/06/2011 - 04:56
hello dear bloogers, i wish all he students attending gpat and oteh examinations "BEST OF LUCK" give your best. here i present the topics for the month may: in this month we shall concentrate on solid dosage form. more precisesly on Tablets and capsules. nandini: 1) an introduction and classification of tablets 2) an introduction and classification of capsules narmadha

strategies to overcmome dose dumping

Submitted by tegkmurthy on Wed, 03/30/2011 - 17:58
Solubility of polymer in gastric fluid and the solvent employed for administration of the formulation are to be considered in design of controlled drug delivery systems. The polymer with least solubility in these fluids avoids the possible dose dumping. pH independent polymers and pH dependent polymers soluble in intestinal polymers are preferable to prevent the dose dumping risk. Diffusion controlled systems are preferable compared to dissolution controlled systems go prevent dose dumping. Matrix controlled system are best suited rather than membrane controlled systems.

LIQUID ORALS : SYRUPS AND ELIXIRS

Submitted by satyajeeth_pandey on Tue, 03/22/2011 - 15:25

SYRUPS

Syrups consists of sugar in water. These are highly concentrated, obviously viscous preparations. And they may or may not contain therapeutic agent.

In simple syrup sucrose at the concentration of 85% is dissolved in water. These are sometimes used as a coating on to the surface of the tablets.

If some therapeutic agent is present, then it is called as medicated syrup.

Pharmaceutics is it an Art or Science?!!!!!!!!!!!!!!!!

Submitted by AymanWaddad on Mon, 02/28/2011 - 15:45

The word pharmaceutics in pharmacy reflect many subject areas which are all associated with the steps involved in producing of our final finished products [1] . The question is, are all pharmacists qualified to be involved in pharmaceutical industry and production?

TABLET.. AN UNIQUE DOSAGE FORM

Submitted by satyajeeth_pandey on Wed, 02/16/2011 - 03:08
According to IP "tablets are solid dosage forms each containing a unit dose of one or more ingredients".(1) 90%of the drugs thar are administered to produce systemic effect are through oral dosage forms. The advantage of the tablets and the capsules over liquid dosage forms includes elixirs, syrups,solutions is that the exact dose of the drug can be given to the patient.(2)

Orally disintegrating tablets using multiparticulates

Submitted by sailesh on Tue, 02/15/2011 - 13:39

Orally disintegrating tablets also called as fast dissolving or mouth dissolving tablets are such kind of dosage forms which when placed in mouth disintegrates rapidly in a matter of seconds(1). They are different from lozenges or buccal tablets which require more than a minute to get dissolved in mouth(1). Any dosage form or a novel drug delivery system which improves patient compliance is of great interest to scientists in which orally disintegrating tablets stands first among them.